Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment
Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosi...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2014.00051 |
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| _version_ | 1841563119122382848 |
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| author | Olugbenga T. Okusanya Charuhas Deshpande Eduardo M. Barbosa Charu Aggarwal Charles B. Simone Jack Jiang Ryan Judy Elizabeth DeJesus Steve Albelda Shuming Nie Philip S. Low Sunil Singhal |
| author_facet | Olugbenga T. Okusanya Charuhas Deshpande Eduardo M. Barbosa Charu Aggarwal Charles B. Simone Jack Jiang Ryan Judy Elizabeth DeJesus Steve Albelda Shuming Nie Philip S. Low Sunil Singhal |
| author_sort | Olugbenga T. Okusanya |
| collection | DOAJ |
| description | Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed to initiate treatment and to direct therapy. We sought to determine if a targeted fluorescent intraoperative molecular imaging technique could be applied in a clinical setting to assist a surgical biopsy in a “hostile” field. We describe the use of a folate-fluorescein conjugate to direct the biopsy of a suspected recurrent lung adenocarcinoma invading the mediastinum that had been previously treated with chemoradiation. We found that intraoperative imaging allowed the identification of small viable tumor deposits that were otherwise indistinguishable from scar and necrosis. Our operative observations were confirmed by histology, fluorescence microscopy, and immunohistochemistry. Our results demonstrate one possible application and clinical value of intraoperative molecular imaging. |
| format | Article |
| id | doaj-art-03c71ad321ad40989173b15a99b787a2 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-03c71ad321ad40989173b15a99b787a22025-01-03T00:11:46ZengSAGE PublishingMolecular Imaging1536-01212015-01-011410.2310/7290.2014.0005110.2310_7290.2014.00051Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical EnvironmentOlugbenga T. OkusanyaCharuhas DeshpandeEduardo M. BarbosaCharu AggarwalCharles B. SimoneJack JiangRyan JudyElizabeth DeJesusSteve AlbeldaShuming NiePhilip S. LowSunil SinghalSurgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed to initiate treatment and to direct therapy. We sought to determine if a targeted fluorescent intraoperative molecular imaging technique could be applied in a clinical setting to assist a surgical biopsy in a “hostile” field. We describe the use of a folate-fluorescein conjugate to direct the biopsy of a suspected recurrent lung adenocarcinoma invading the mediastinum that had been previously treated with chemoradiation. We found that intraoperative imaging allowed the identification of small viable tumor deposits that were otherwise indistinguishable from scar and necrosis. Our operative observations were confirmed by histology, fluorescence microscopy, and immunohistochemistry. Our results demonstrate one possible application and clinical value of intraoperative molecular imaging.https://doi.org/10.2310/7290.2014.00051 |
| spellingShingle | Olugbenga T. Okusanya Charuhas Deshpande Eduardo M. Barbosa Charu Aggarwal Charles B. Simone Jack Jiang Ryan Judy Elizabeth DeJesus Steve Albelda Shuming Nie Philip S. Low Sunil Singhal Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment Molecular Imaging |
| title | Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment |
| title_full | Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment |
| title_fullStr | Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment |
| title_full_unstemmed | Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment |
| title_short | Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment |
| title_sort | molecular imaging to identify tumor recurrence following chemoradiation in a hostile surgical environment |
| url | https://doi.org/10.2310/7290.2014.00051 |
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