Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models

Abstract We investigated whether miR143#12, a synthesized chemically modified miR-143-3p derivative, exerts therapeutic effects on acute myocardial infarction (AMI). Sprague–Dawley rats and Japanese white rabbits underwent 30 min of coronary occlusion followed by 2 weeks of reperfusion. The rat AMI...

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Bibliographic Details
Main Authors:	Shingo Minatoguchi, Nobuhiko Sugito, Kazuki Heishima, Yuko Ito, Remi Nakashima, Hiroyuki Okura, Yukihiro Akao, Shinya Minatoguchi
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Series:	Scientific Reports
Subjects:	Chemically modified miR143 Myocardial infarction Infarct size Cardiac function Autophagic cell death Angiogenesis
Online Access:	https://doi.org/10.1038/s41598-024-76429-3
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Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models

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