Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer

Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer

Abstract Viral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics. In the emerging field of DNA and particularly RNA‐based gene therapies,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jeremy L. Pinyon, Georg vonJonquieres, Stephen L. Mow, Amr Al Abed, Keng‐Yin Lai, Mathumathi Manoharan, Edward N. Crawford, Stanley H. Xue, Sarah Smith‐Moore, Lisa J. Caproni, Sarah Milsom, Matthias Klugmann, Nigel H. Lovell, Gary D. Housley
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	Advanced Science
Subjects:	DNA and RNA vaccines electric field focusing nonviral gene therapy nucleic acid electrotransfer precision gene delivery platform
Online Access:	https://doi.org/10.1002/advs.202406545
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Current issues with antibody-conjugated lipid nanoparticles
by: Aayush
Published: (2025-02-01)

Nonviral targeted mRNA delivery: principles, progresses, and challenges
by: Xi He, et al.
Published: (2025-01-01)

Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy
by: LIU Siyu, et al.
Published: (2024-12-01)

Dynamic Study of a Capacitive MEMS Switch with Double Clamped-Clamped Microbeams
by: Hatem Samaali, et al.
Published: (2014-01-01)

A preliminary evaluation of a fast, low-cost, and high-throughput nucleic acid extraction method for bacterial microbiota profiling in low-microbial biomass samples
by: Xiangning Bai, et al.
Published: (2025-01-01)

Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform
by: Tommaso Tabaglio, et al.
Published: (2025-03-01)

Molecular detection of pore-forming leuko toxin in methicillin resistant Staphylococcus aureus isolated from skin infection
by: Sara A. Al-Ghazal, et al.
Published: (2024-01-01)

Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants
by: Li Yang, et al.
Published: (2025-01-01)

Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation
by: Lucia Landi, et al.
Published: (2025-01-01)

MOBILIZATION AND CONSERVATION OF THE SEED POOL OF PLANT GENETIC RESOURCES IN AZERBAIJAN
by: Z. I. Akparov, et al.
Published: (2014-12-01)

Investigation of dgat1 and prnp gene polymorphism of various cattle breeds in turkey
by: İclal Şahin, et al.

Study of some virulence genes from uropathogenic Klebsiella pneumoniae and Pseudomonas aeruginosa isolated in Wasit Province, Iraq
by: Rana H. Raheema, et al.
Published: (2024-01-01)

FLAVONOID BIOSYNTHESIS GENES IN WHEAT
by: E. K. Khlestkina, et al.
Published: (2015-01-01)

Meta-QTL analysis for mining of candidate genes and constitutive gene network development for viral disease resistance in maize (Zea mays L.)
by: Mamta Gupta, et al.
Published: (2025-01-01)

Peptide nucleic acid (PNA) clamps reduce amplification of host chloroplast and mitochondria rRNA gene sequences and increase detected diversity in 16S rRNA gene profiling analysis of oak-associated microbiota
by: Usman Hussain, et al.
Published: (2025-01-01)

Genome-wide identification and functional roles relating to anthocyanin biosynthesis analysis in maize
by: Xiaofang Wang, et al.
Published: (2025-01-01)

Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach
by: Sivapriya Dayakar, et al.
Published: (2025-01-01)

In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney
by: Toshiki Tsuboi, et al.
Published: (2025-03-01)

Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment
by: Ullah A, et al.
Published: (2025-01-01)

On learning molecular biology in François Gros’ lab in the late 1970s and early 1980s
by: Minty, Adrian
Published: (2023-12-01)

Classification of Genes Based on Age-Related Differential Expression in Breast Cancer
by: Gunhee Lee, et al.
Published: (2017-12-01)

COMPARATIVE CHARACTERISTICS OF PUCCINIA RECONDITA ROB. EX DESM. SYN.: PUCCINIA TRITICI ERIKSS. VIRULENCE IN MIDDLE VOLGA REGION
by: L. G. Tyryshkin, et al.
Published: (2015-01-01)

Reconstructing the genetic structure of the Kazakh from clan distribution data
by: M. K. Zhabagin, et al.
Published: (2018-11-01)

Detection of OmpA and blaPER-1 Genes and Biofilm Formation in Acinetobacter baumannii Clinical Isolates
by: Ban Abdulsattar, et al.
Published: (2025-01-01)

Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast
by: David Figueroa, et al.
Published: (2025-02-01)

Localization of rust resistance genes in old local Russian flaxes by methods of classical genetics
by: S. N. Kutuzova, et al.
Published: (2019-10-01)

Phylostratigraphic analysis of gene networks of human diseases
by: Z. S. Mustafin, et al.
Published: (2021-03-01)

Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus
by: Jordan M. Sampson, et al.
Published: (2025-01-01)

Prevalence of carbapenemase-encoding genes carriage in patients admitted to multidisciplinary hospital in Moscow
by: Ni O.G., et al.
Published: (2024-09-01)

Isolation, identification and characteristics of Aeromonas sobria from diseased rainbow trout (Oncorhynchus mykiss)
by: Li-Ping Liu, et al.
Published: (2025-01-01)

Approaches and applications in transdermal and transpulmonary gene drug delivery
by: Anni Zhang, et al.
Published: (2025-01-01)

Evolutionary and functional divergence of Sfx, a plasmid-encoded H-NS homolog, underlies the regulation of IncX plasmid conjugation
by: Avril Wang, et al.
Published: (2025-02-01)

Genetic Association Analysis of Fasting and 1- and 2-Hour Glucose Tolerance Test Data Using a Generalized Index of Dissimilarity Measure for the Korean Population
by: Jaeyong Yee, et al.
Published: (2016-12-01)

THE NATIONAL BANK OF PLANT GENETIC RESOURCES OF UKRAINE AS THE EMBODIMENT OF N.I. VAVILOV’S IDEAS
by: V. K. Ryabchoun, et al.
Published: (2014-12-01)

Expression evaluation of exogenous and endogenous alcohol dehydrogenase genes in transgenic Arabidopsis
by: Haoqiang Yu, et al.
Published: (2025-01-01)

In silico sequence and structure prediction analysis of biomarker genes in Aeromonas sp. of Andaman and Nicobar Islands
by: Balakrishnan Meena, et al.
Published: (2025-06-01)

THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES
by: Ugo Testa, et al.
Published: (2024-08-01)

On-Chip DNA Assembly via Dielectrophoresis
by: Xichuan Rui, et al.
Published: (2025-01-01)

Comparison of different developmental stages of jujube (Ziziphus jujuba) fruit and identification of Hub genes
by: Li Yalan, et al.
Published: (2024-12-01)

Effects of butyric acid glycerol ester supplementation on intestinal nutrient transporter and immune-related genes in broiler chickens challenged with Eimeria maxima
by: Kouassi R. Kpodo, et al.
Published: (2025-01-01)