Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis

Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis

Late graft thrombosis is an infrequent yet severe complication post renal transplantation, profoundly affecting graft survival and patient prognosis. We report a case of a 29-year-old male with end-stage renal disease due to IgA nephropathy who underwent ABO-incompatible renal transplantation. Despi...

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Bibliographic Details
Main Authors: Abhishek Pratap Singh, Pankaj Beniwal, Vinay Malhotra
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Indian Journal of Transplantation
Subjects:
abo-incompatible transplantation
antibody-mediated rejection
desensitization
graft loss
high-risk transplant scenarios
immunosuppression
renal allograft thrombosis
renal transplantation complications
thrombotic microangiopathy
treatment challenges
Online Access:https://journals.lww.com/10.4103/ijot.ijot_61_24
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Summary:Late graft thrombosis is an infrequent yet severe complication post renal transplantation, profoundly affecting graft survival and patient prognosis. We report a case of a 29-year-old male with end-stage renal disease due to IgA nephropathy who underwent ABO-incompatible renal transplantation. Despite effective desensitization, the patient experienced late graft thrombosis 3 months posttransplant, resulting in irreversible graft failure and necessitating hemodialysis initiation. This case underscores the complexities of late graft thrombosis and emphasizes the significance of timely identification and intervention for optimizing transplant outcomes.
ISSN:2212-0017
2212-0025

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