Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center
BackgroundThe COVID-19 pandemic has raised concerns about various neurological complications, including Guillain-Barré syndrome (GBS). Understanding the characteristics and incidence of GBS during this period is crucial for clinical management and public health response.ObjectiveThis study aims to a...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1565912/full |
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| author | Mohammadali Arami Rezafarhad Manteghifasaei Mohammad Karimi Puya Zandi Mobina Javadi |
| author_facet | Mohammadali Arami Rezafarhad Manteghifasaei Mohammad Karimi Puya Zandi Mobina Javadi |
| author_sort | Mohammadali Arami |
| collection | DOAJ |
| description | BackgroundThe COVID-19 pandemic has raised concerns about various neurological complications, including Guillain-Barré syndrome (GBS). Understanding the characteristics and incidence of GBS during this period is crucial for clinical management and public health response.ObjectiveThis study aims to analyze the characteristics of GBS cases reported at an Iranian referral center during the COVID-19 pandemic and assess the relationship between GBS, COVID-19 infection, and vaccination.MethodsWe conducted a retrospective analysis of GBS cases referred to our center between 2018 and 2023. Clinical data, including demographic information, neurophysiological subtypes, COVID-19 and vaccination associated cases and outcomes were collected and analyzed. The frequency of GBS admission during pandemic compared with previous years. Characteristics of COVID-19 associated GBS and those vaccinated for COVID-19 was compared.ResultsA total of 334 patients were included to study. Our analysis revealed a notable increase in GBS cases during the pandemic. The incidence of vaccine-related GBS was significantly lower than that of GBS related to COVID-19 infection. Additionally, GBS patients diagnosed with COVID-19 presented more severe symptoms compared to those who developed GBS after vaccination.ConclusionAlthough the incidence of GBS increased during the COVID-19 pandemic at our center, it remains a rare complication of both COVID-19 and its vaccination. These findings highlight the need for ongoing surveillance of neurological complications during infectious disease outbreaks and vaccination campaigns. |
| format | Article |
| id | doaj-art-03a7e3a1b63a4c0e8f7f39ea7e4bba03 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-03a7e3a1b63a4c0e8f7f39ea7e4bba032025-08-20T03:53:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15659121565912Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral centerMohammadali Arami0Rezafarhad Manteghifasaei1Mohammad Karimi2Puya Zandi3Mobina Javadi4Department of Neurology, Milad General Hospital, Tehran, IranDepartment of Neurology, Milad General Hospital, Tehran, IranDepartment of Neurology, Milad General Hospital, Tehran, IranDepartment of Neurology, Milad General Hospital, Tehran, IranFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranBackgroundThe COVID-19 pandemic has raised concerns about various neurological complications, including Guillain-Barré syndrome (GBS). Understanding the characteristics and incidence of GBS during this period is crucial for clinical management and public health response.ObjectiveThis study aims to analyze the characteristics of GBS cases reported at an Iranian referral center during the COVID-19 pandemic and assess the relationship between GBS, COVID-19 infection, and vaccination.MethodsWe conducted a retrospective analysis of GBS cases referred to our center between 2018 and 2023. Clinical data, including demographic information, neurophysiological subtypes, COVID-19 and vaccination associated cases and outcomes were collected and analyzed. The frequency of GBS admission during pandemic compared with previous years. Characteristics of COVID-19 associated GBS and those vaccinated for COVID-19 was compared.ResultsA total of 334 patients were included to study. Our analysis revealed a notable increase in GBS cases during the pandemic. The incidence of vaccine-related GBS was significantly lower than that of GBS related to COVID-19 infection. Additionally, GBS patients diagnosed with COVID-19 presented more severe symptoms compared to those who developed GBS after vaccination.ConclusionAlthough the incidence of GBS increased during the COVID-19 pandemic at our center, it remains a rare complication of both COVID-19 and its vaccination. These findings highlight the need for ongoing surveillance of neurological complications during infectious disease outbreaks and vaccination campaigns.https://www.frontiersin.org/articles/10.3389/fneur.2025.1565912/fullGuillain-Barré syndromeCOVID-19COVID 19 vaccine complicationsacute motor axonal neuropathy (AMAN)acute inflammatory demyelinating polyneuropathy (AIDP) |
| spellingShingle | Mohammadali Arami Rezafarhad Manteghifasaei Mohammad Karimi Puya Zandi Mobina Javadi Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center Frontiers in Neurology Guillain-Barré syndrome COVID-19 COVID 19 vaccine complications acute motor axonal neuropathy (AMAN) acute inflammatory demyelinating polyneuropathy (AIDP) |
| title | Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center |
| title_full | Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center |
| title_fullStr | Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center |
| title_full_unstemmed | Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center |
| title_short | Impact of COVID-19 on Guillain Barre Syndrome (GBS) insights from an Iranian referral center |
| title_sort | impact of covid 19 on guillain barre syndrome gbs insights from an iranian referral center |
| topic | Guillain-Barré syndrome COVID-19 COVID 19 vaccine complications acute motor axonal neuropathy (AMAN) acute inflammatory demyelinating polyneuropathy (AIDP) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1565912/full |
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