Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial
Abstract The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) an...
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Sociedade Brasileira de Pesquisa Odontológica
2024-11-01
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| Series: | Brazilian Oral Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000100704&lng=en&tlng=en |
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| author | Karla Pinheiro de Alencar Daniel Fernandes Peixoto Fábio do Nascimento Máximo Isabela Albuquerque Passos Farias Fábio Correia Sampaio |
| author_facet | Karla Pinheiro de Alencar Daniel Fernandes Peixoto Fábio do Nascimento Máximo Isabela Albuquerque Passos Farias Fábio Correia Sampaio |
| author_sort | Karla Pinheiro de Alencar |
| collection | DOAJ |
| description | Abstract The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) and a DMFT index of less than 12. Each participant was exposed to nine OLMs and a 10% sucrose solution (positive control) as part of the crossover design. The pH of the dental biofilm was measured with a Beetrode® microelectrode at 0, 5, 10, 15, 20, 25, and 30 min. Statistical analysis was performed to determine the minimum pH and the area under the curve (AUC). One-way ANOVA was utilized, and the significance level was set at 0.05. Pediatric OLMs caused a sucrose-like decrease in biofilm pH, regardless of therapeutic class (p > 0.05). The mean ± standard deviation of the AUC ranged from 16.26 ± 11.59 (cetirizine) to 39.22 ± 20.81 (azithromycin), with no statistically significant difference compared to sucrose (25.22 ± 6.97) (p > 0.05). The findings suggest that pediatric OLMs contribute to dental biofilm acidogenicity, with a more pronounced effect induced by medications used for respiratory diseases and also by antibiotics. |
| format | Article |
| id | doaj-art-03951a50a9a94a9c8d3b6f12d6204f79 |
| institution | Kabale University |
| issn | 1807-3107 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj-art-03951a50a9a94a9c8d3b6f12d6204f792024-11-12T07:48:47ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072024-11-013810.1590/1807-3107bor-2024.vol38.0107Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trialKarla Pinheiro de Alencarhttps://orcid.org/0000-0002-9416-9012Daniel Fernandes Peixotohttps://orcid.org/0009-0009-5409-1597Fábio do Nascimento Máximohttps://orcid.org/0009-0008-1252-3665Isabela Albuquerque Passos Fariashttps://orcid.org/0000-0002-3601-1698Fábio Correia Sampaiohttps://orcid.org/0000-0003-2870-5742Abstract The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) and a DMFT index of less than 12. Each participant was exposed to nine OLMs and a 10% sucrose solution (positive control) as part of the crossover design. The pH of the dental biofilm was measured with a Beetrode® microelectrode at 0, 5, 10, 15, 20, 25, and 30 min. Statistical analysis was performed to determine the minimum pH and the area under the curve (AUC). One-way ANOVA was utilized, and the significance level was set at 0.05. Pediatric OLMs caused a sucrose-like decrease in biofilm pH, regardless of therapeutic class (p > 0.05). The mean ± standard deviation of the AUC ranged from 16.26 ± 11.59 (cetirizine) to 39.22 ± 20.81 (azithromycin), with no statistically significant difference compared to sucrose (25.22 ± 6.97) (p > 0.05). The findings suggest that pediatric OLMs contribute to dental biofilm acidogenicity, with a more pronounced effect induced by medications used for respiratory diseases and also by antibiotics.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000100704&lng=en&tlng=enDental PlaqueAdministrationOralDental Caries |
| spellingShingle | Karla Pinheiro de Alencar Daniel Fernandes Peixoto Fábio do Nascimento Máximo Isabela Albuquerque Passos Farias Fábio Correia Sampaio Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial Brazilian Oral Research Dental Plaque Administration Oral Dental Caries |
| title | Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial |
| title_full | Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial |
| title_fullStr | Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial |
| title_full_unstemmed | Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial |
| title_short | Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial |
| title_sort | dental biofilm acidogenicity induced by pediatric oral medications a double blind randomized clinical trial |
| topic | Dental Plaque Administration Oral Dental Caries |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000100704&lng=en&tlng=en |
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