Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties
Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) deri...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699810 |
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| author | Xiaoke Wang Yue Zhang Hui Kong Jinjun Cheng Meiling Zhang Ziwei Sun Suna Wang Jiaxing Liu Huihua Qu Yan Zhao |
| author_facet | Xiaoke Wang Yue Zhang Hui Kong Jinjun Cheng Meiling Zhang Ziwei Sun Suna Wang Jiaxing Liu Huihua Qu Yan Zhao |
| author_sort | Xiaoke Wang |
| collection | DOAJ |
| description | Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26–9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine. |
| format | Article |
| id | doaj-art-0384e62fbf2a4882b82fd834e40ff4bf |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-0384e62fbf2a4882b82fd834e40ff4bf2025-08-20T04:02:41ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-01481687610.1080/21691401.2019.1699810Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory propertiesXiaoke Wang0Yue Zhang1Hui Kong2Jinjun Cheng3Meiling Zhang4Ziwei Sun5Suna Wang6Jiaxing Liu7Huihua Qu8Yan Zhao9School of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Preclinical Medicine, Beijing Key Laboratory, Beijing University of Chinese Medicine, Beijing, ChinaMulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26–9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine.https://www.tandfonline.com/doi/10.1080/21691401.2019.1699810Mulberry silkworm cocoon carbonisatacarbon dotsanti-inflammatorydrug discovery |
| spellingShingle | Xiaoke Wang Yue Zhang Hui Kong Jinjun Cheng Meiling Zhang Ziwei Sun Suna Wang Jiaxing Liu Huihua Qu Yan Zhao Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties Artificial Cells, Nanomedicine, and Biotechnology Mulberry silkworm cocoon carbonisata carbon dots anti-inflammatory drug discovery |
| title | Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties |
| title_full | Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties |
| title_fullStr | Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties |
| title_full_unstemmed | Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties |
| title_short | Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties |
| title_sort | novel mulberry silkworm cocoon derived carbon dots and their anti inflammatory properties |
| topic | Mulberry silkworm cocoon carbonisata carbon dots anti-inflammatory drug discovery |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1699810 |
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