Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient
This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spa...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224004454 |
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| author | Charles Gibert Marie Wan Matthieu Arsicot Ugo Huvelle Thomas Penhoat Yatrika Koumar Charline Miossec Florence Persat Florent Valour Jean Menotti Pauline Tirard-Collet |
| author_facet | Charles Gibert Marie Wan Matthieu Arsicot Ugo Huvelle Thomas Penhoat Yatrika Koumar Charline Miossec Florence Persat Florent Valour Jean Menotti Pauline Tirard-Collet |
| author_sort | Charles Gibert |
| collection | DOAJ |
| description | This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area. Long-term suppressive antifungal therapy with voriconazole and subsequently with posaconazole, combined with multiple surgical procedures, led to an improvement in the patient's condition. This case highlights the importance of considering a patient's comprehensive microbiological history and reassessing antimicrobial therapy in cases of nonimprovement or relapse. |
| format | Article |
| id | doaj-art-036fae62c9254c41b2a39b923b801863 |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-036fae62c9254c41b2a39b923b8018632025-01-09T06:13:29ZengElsevierInternational Journal of Infectious Diseases1201-97122025-02-01151107370Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patientCharles Gibert0Marie Wan1Matthieu Arsicot2Ugo Huvelle3Thomas Penhoat4Yatrika Koumar5Charline Miossec6Florence Persat7Florent Valour8Jean Menotti9Pauline Tirard-Collet10Institut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, FranceService de maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; CRIVasC (Centre de Référence des Infections Vasculaires Complexes), Service de Chirurgie Vasculaire et Endovasculaire, Hospices civils de Lyon, Lyon, FranceCRIVasC (Centre de Référence des Infections Vasculaires Complexes), Service de Chirurgie Vasculaire et Endovasculaire, Hospices civils de Lyon, Lyon, FranceCRIVasC (Centre de Référence des Infections Vasculaires Complexes), Service de Chirurgie Vasculaire et Endovasculaire, Hospices civils de Lyon, Lyon, FranceService de Médecine Nucléaire, Hospices Civils de Lyon, Lyon, FranceService des Maladies Infectieuses, Centre Hospitalier Universitaire Réunion, Site de Saint Pierre, La Réunion, FranceInstitut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, FranceInstitut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, France; UR 3738-CICLY-Equipe Inflammation et Immunité de L'épithélium Respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, FranceService de maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France; CIRI - Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Lyon, FranceInstitut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, France; UR 3738-CICLY-Equipe Inflammation et Immunité de L'épithélium Respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, FranceInstitut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, France; UR 3738-CICLY-Equipe Inflammation et Immunité de L'épithélium Respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France; Corresponding author: Tel: +33-4-72-07-11-11; fax: +33-4-72-07-18 73.This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area. Long-term suppressive antifungal therapy with voriconazole and subsequently with posaconazole, combined with multiple surgical procedures, led to an improvement in the patient's condition. This case highlights the importance of considering a patient's comprehensive microbiological history and reassessing antimicrobial therapy in cases of nonimprovement or relapse.http://www.sciencedirect.com/science/article/pii/S1201971224004454Magnusiomyces capitatusGeotrichum capitatumSaprochaete capitataRare yeast invasive infectionMycotic aneurysm |
| spellingShingle | Charles Gibert Marie Wan Matthieu Arsicot Ugo Huvelle Thomas Penhoat Yatrika Koumar Charline Miossec Florence Persat Florent Valour Jean Menotti Pauline Tirard-Collet Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient International Journal of Infectious Diseases Magnusiomyces capitatus Geotrichum capitatum Saprochaete capitata Rare yeast invasive infection Mycotic aneurysm |
| title | Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| title_full | Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| title_fullStr | Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| title_full_unstemmed | Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| title_short | Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| title_sort | mycotic aneurysm due to magnusiomyces capitatus complicating a second liver transplant in a colonized patient |
| topic | Magnusiomyces capitatus Geotrichum capitatum Saprochaete capitata Rare yeast invasive infection Mycotic aneurysm |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224004454 |
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