Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study
Background: Numbness and tingling secondary to chemotherapy-induced peripheral neuropathy (CIPN) are frequent side effects that limit chemotherapy treatment and quality of life. Successful treatments for CIPN are limited. This preliminary report shows the potential long-term effects of ozone treatme...
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SAGE Publishing
2025-01-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354241307038 |
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| author | Bernardino Clavo MD, PhD Delvys Rodríguez-Abreu MD, PhD Saray Galván-Ruiz MD Mario Federico MD, PhD Angeles Cánovas-Molina RN Yolanda Ramallo-Fariña MSc Carla Antonilli MD Gretel Benítez MD Himar Fabelo BEng MSc, PhD Carla García-Lourve RN, MRes Damián González-Beltrán CNS, MSc Ignacio J. Jorge MD, PhD Francisco Rodríguez-Esparragón BSc, PhD Gustavo M. Callico MEng, PhD |
| author_facet | Bernardino Clavo MD, PhD Delvys Rodríguez-Abreu MD, PhD Saray Galván-Ruiz MD Mario Federico MD, PhD Angeles Cánovas-Molina RN Yolanda Ramallo-Fariña MSc Carla Antonilli MD Gretel Benítez MD Himar Fabelo BEng MSc, PhD Carla García-Lourve RN, MRes Damián González-Beltrán CNS, MSc Ignacio J. Jorge MD, PhD Francisco Rodríguez-Esparragón BSc, PhD Gustavo M. Callico MEng, PhD |
| author_sort | Bernardino Clavo MD, PhD |
| collection | DOAJ |
| description | Background: Numbness and tingling secondary to chemotherapy-induced peripheral neuropathy (CIPN) are frequent side effects that limit chemotherapy treatment and quality of life. Successful treatments for CIPN are limited. This preliminary report shows the potential long-term effects of ozone treatment in the management of persistent numbness and tingling secondary to CIPN. Methods: Ozone treatment was administered by rectal insufflation in 15 patients (female/male: 8/7, age: 66 years old) suffering from persistent numbness and tingling secondary to grade-2 or grade-3 CIPN. Planned ozone treatment consisted of 40 sessions over 4 months. The initial concentration of 10 μg/mL was progressively increased to 30 μg/mL. The initial gas volume of 180 mL/session was progressively increased to 300 mL/session if tolerated. Before and after ozone treatment, and at 3- and 6- months after the end of treatment, they were assessed (i) the grade of CIPN-toxicity, and (ii) the self-reported decrease in numbness and tingling. Results: After ozone treatment, 47% of patients experienced a decrease in the grade of CIPN-toxicity ( P = .016), and 67% of patients reported a decrease in numbness and tingling ≥50% ( P = .002). These effects were maintained at 3- and 6- months after the end of O 3 T. Conclusions: In this retrospective report, patients with persistent numbness and tingling secondary to CIPN showed clinically relevant and long-term improvements after ozone treatment. The magnitude and duration of the observed effects merit further research and support our ongoing clinical trials. |
| format | Article |
| id | doaj-art-0357580aeb084f9e997c7beda38fe8e3 |
| institution | Kabale University |
| issn | 1552-695X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
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| series | Integrative Cancer Therapies |
| spelling | doaj-art-0357580aeb084f9e997c7beda38fe8e32025-01-11T14:03:36ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2025-01-012410.1177/15347354241307038Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective StudyBernardino Clavo MD, PhD0Delvys Rodríguez-Abreu MD, PhD1Saray Galván-Ruiz MD2Mario Federico MD, PhD3Angeles Cánovas-Molina RN4Yolanda Ramallo-Fariña MSc5Carla Antonilli MD6Gretel Benítez MD7Himar Fabelo BEng MSc, PhD8Carla García-Lourve RN, MRes9Damián González-Beltrán CNS, MSc10Ignacio J. Jorge MD, PhD11Francisco Rodríguez-Esparragón BSc, PhD12Gustavo M. Callico MEng, PhD13Spanish Group of Clinical Research in Radiation Oncology (GICOR), Madrid, SpainComplejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainServicio de Evaluación y Planificación del Servicio Canario de Salud (SESCS), Santa Cruz de Tenerife, SpainHospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainComplejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, SpainUniversity of Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainHospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainCIBERINFEC, Instituto de Salud Carlos III, Madrid, SpainUniversity of Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, SpainBackground: Numbness and tingling secondary to chemotherapy-induced peripheral neuropathy (CIPN) are frequent side effects that limit chemotherapy treatment and quality of life. Successful treatments for CIPN are limited. This preliminary report shows the potential long-term effects of ozone treatment in the management of persistent numbness and tingling secondary to CIPN. Methods: Ozone treatment was administered by rectal insufflation in 15 patients (female/male: 8/7, age: 66 years old) suffering from persistent numbness and tingling secondary to grade-2 or grade-3 CIPN. Planned ozone treatment consisted of 40 sessions over 4 months. The initial concentration of 10 μg/mL was progressively increased to 30 μg/mL. The initial gas volume of 180 mL/session was progressively increased to 300 mL/session if tolerated. Before and after ozone treatment, and at 3- and 6- months after the end of treatment, they were assessed (i) the grade of CIPN-toxicity, and (ii) the self-reported decrease in numbness and tingling. Results: After ozone treatment, 47% of patients experienced a decrease in the grade of CIPN-toxicity ( P = .016), and 67% of patients reported a decrease in numbness and tingling ≥50% ( P = .002). These effects were maintained at 3- and 6- months after the end of O 3 T. Conclusions: In this retrospective report, patients with persistent numbness and tingling secondary to CIPN showed clinically relevant and long-term improvements after ozone treatment. The magnitude and duration of the observed effects merit further research and support our ongoing clinical trials.https://doi.org/10.1177/15347354241307038 |
| spellingShingle | Bernardino Clavo MD, PhD Delvys Rodríguez-Abreu MD, PhD Saray Galván-Ruiz MD Mario Federico MD, PhD Angeles Cánovas-Molina RN Yolanda Ramallo-Fariña MSc Carla Antonilli MD Gretel Benítez MD Himar Fabelo BEng MSc, PhD Carla García-Lourve RN, MRes Damián González-Beltrán CNS, MSc Ignacio J. Jorge MD, PhD Francisco Rodríguez-Esparragón BSc, PhD Gustavo M. Callico MEng, PhD Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study Integrative Cancer Therapies |
| title | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study |
| title_full | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study |
| title_fullStr | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study |
| title_full_unstemmed | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study |
| title_short | Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study |
| title_sort | long term effects of ozone treatment in patients with persistent numbness and tingling secondary to chemotherapy induced peripheral neuropathy a retrospective study |
| url | https://doi.org/10.1177/15347354241307038 |
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