Discovery of miRNA–mRNA regulatory networks in glioblastoma reveals novel insights into tumor microenvironment remodeling

Discovery of miRNA–mRNA regulatory networks in glioblastoma reveals novel insights into tumor microenvironment remodeling

Abstract Adult glioblastoma (GBM) is a highly aggressive primary brain tumor, accounting for nearly half of all malignant brain tumors, with a median survival rate of only 8 months. Treatment for GBM is largely ineffective due to the highly invasive nature and complex tumor composition of this malig...

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Bibliographic Details
Main Authors: Iulia A. Grigore, Athulram Rajagopal, Jonathan Tak-Sum Chow, Thomas J. Stone, Leonardo Salmena
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
microRNA
Glioblastoma
Tumor microenvironment
Extracellular matrix
Growth signaling
Online Access:https://doi.org/10.1038/s41598-024-78337-y
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