T cell responses in repeated controlled human schistosome infection compared to natural exposure

T cell responses in repeated controlled human schistosome infection compared to natural exposure

Abstract In Schistosoma-endemic regions a lack of natural sterilizing immunity means individuals are repeatedly infected, treated and reinfected. Due to difficulties in tracking natural infection, kinetics of host immune response during these reinfections have not been elucidated. Here, we use repea...

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Main Authors: Emmanuella Driciru, Jan Pieter R. Koopman, Sanne Steenbergen, Friederike Sonnet, Koen A. Stam, Laura de Bes-Roeleveld, Eva Iliopoulou, Jacqueline J. Janse, Jeroen Sijtsma, Irene Nambuya, Stan T. Hilt, Marion König, Yvonne Kruize, Miriam Casacuberta-Partal, Moses Egesa, Govert J. van Dam, Paul L. A. M. Corstjens, Lisette van Lieshout, Harriet Mpairwe, Andrew S. MacDonald, Maria Yazdanbakhsh, Alison M. Elliott, Meta Roestenberg, Emma L. Houlder
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62144-8
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