Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer

Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer

Abstract Purpose Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, the mechanism of action of PTT and its connection to pyroptosis as well as the therapeutic potential of PTT...

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Bibliographic Details
Main Authors: Yanyan Hu, ErPeng Qi, Chao Yun, Xi Li, Fangyi Liu, Zhigang Cheng, Na Guan, Qiong Wang, Huixia Zhao, Wenhua Xiao, Liang Peng, Jingwen Yang, Xiaoling Yu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Pyroptosis
Photothermal therapy
Pancreatic cancer
STING agonist
GSDMD
Online Access:https://doi.org/10.1186/s12967-025-06247-2
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