KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis

KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis

BackgroundAcute lung injury (ALI) is a severe condition characterized by inflammation, tissue damage, and persistent activation of the cyclic GMP-AMP (cGAS)-stimulator of interferon genes (STING) pathway, which exacerbates the production of pro-inflammatory mediators and promotes the progression of...

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Bibliographic Details
Main Authors: Yonghu Chen, Xilin Wu, Zhe Jiang, Xuezheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
KAE
cGAS-STING
PANoptosis
acute lung injury
intracellular DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1461931/full
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