Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers

Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers

Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a viable strategy to overcome unwanted attributes o...

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Main Authors: Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000888
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