Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus
Abstract Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as a marker for DR in diabetes mellitus (DM) patients. An observational study was conducted with 47 type 2 DM patients and 21 he...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-85021-8 |
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| author | Chen-Yu Lin Yi-Jing Sheen Hsian-Min Chen Yi-An Lu Jun-Peng Chen Hsuan-En Huang Yu-Ju Lin Peng-Tai Tien Chia-Jen Chang Hui-Ju Lin I-Jong Wang Chien-Chih Chou |
| author_facet | Chen-Yu Lin Yi-Jing Sheen Hsian-Min Chen Yi-An Lu Jun-Peng Chen Hsuan-En Huang Yu-Ju Lin Peng-Tai Tien Chia-Jen Chang Hui-Ju Lin I-Jong Wang Chien-Chih Chou |
| author_sort | Chen-Yu Lin |
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| description | Abstract Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as a marker for DR in diabetes mellitus (DM) patients. An observational study was conducted with 47 type 2 DM patients and 21 healthy controls. OCTA measured superficial and deep retinal VD in the parafoveal region. Statistical analyses, including logistic regression and ROC curve analysis, were used to assess the association between VD and DR presence. Results showed that DM patients had lower parafoveal superficial (46.73 vs. 52.37%, p = 0.002) and deep VD (50.35 vs. 54.26%, p = 0.019) compared to controls. Within the DM group, DR patients had lower VD in the superior parafoveal superficial layer (p = 0.042) and temporal parafoveal deep layer (p = 0.035). ROC analysis identified a cutoff of 51.86% for the temporal deep parafoveal VD, with an AUC of 0.697 (p = 0.035) and 81.8% sensitivity for DR discrimination. Reduced VD in the temporal deep parafoveal region is linked to a higher DR likelihood. OCTA-derived VD metrics offer promise for early DR detection and underscore the importance of monitoring vascular changes in DM patients. |
| format | Article |
| id | doaj-art-02d45859bb9a47abb4c2ee8df1123b5f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-02d45859bb9a47abb4c2ee8df1123b5f2025-01-12T12:19:51ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-024-85021-8Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitusChen-Yu Lin0Yi-Jing Sheen1Hsian-Min Chen2Yi-An Lu3Jun-Peng Chen4Hsuan-En Huang5Yu-Ju Lin6Peng-Tai Tien7Chia-Jen Chang8Hui-Ju Lin9I-Jong Wang10Chien-Chih Chou11Department of Ophthalmology, Taichung Veterans General HospitalDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General HospitalCenter for Quantitative Imaging in Medicine (CQUIM), Department of Medical Research, Taichung Veterans General HospitalDepartment of Ophthalmology, Taichung Veterans General HospitalBiostatistics Task Force of Taichung Veterans General HospitalDepartment of Ophthalmology, Taichung Veterans General HospitalDepartment of Family Medicine, Taichung Veterans General HospitalCollege of Medicine, National Chung Hsing UniversityDepartment of Ophthalmology, Taichung Veterans General HospitalEye Center, China Medical University HospitalGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan UniversityDepartment of Ophthalmology, Taichung Veterans General HospitalAbstract Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as a marker for DR in diabetes mellitus (DM) patients. An observational study was conducted with 47 type 2 DM patients and 21 healthy controls. OCTA measured superficial and deep retinal VD in the parafoveal region. Statistical analyses, including logistic regression and ROC curve analysis, were used to assess the association between VD and DR presence. Results showed that DM patients had lower parafoveal superficial (46.73 vs. 52.37%, p = 0.002) and deep VD (50.35 vs. 54.26%, p = 0.019) compared to controls. Within the DM group, DR patients had lower VD in the superior parafoveal superficial layer (p = 0.042) and temporal parafoveal deep layer (p = 0.035). ROC analysis identified a cutoff of 51.86% for the temporal deep parafoveal VD, with an AUC of 0.697 (p = 0.035) and 81.8% sensitivity for DR discrimination. Reduced VD in the temporal deep parafoveal region is linked to a higher DR likelihood. OCTA-derived VD metrics offer promise for early DR detection and underscore the importance of monitoring vascular changes in DM patients.https://doi.org/10.1038/s41598-024-85021-8Diabetic retinopathyOptical coherence tomography angiographyVessel density |
| spellingShingle | Chen-Yu Lin Yi-Jing Sheen Hsian-Min Chen Yi-An Lu Jun-Peng Chen Hsuan-En Huang Yu-Ju Lin Peng-Tai Tien Chia-Jen Chang Hui-Ju Lin I-Jong Wang Chien-Chih Chou Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus Scientific Reports Diabetic retinopathy Optical coherence tomography angiography Vessel density |
| title | Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| title_full | Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| title_fullStr | Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| title_short | Vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| title_sort | vulnerable parafoveal microcirculation quadrant in patients with type 2 diabetes mellitus |
| topic | Diabetic retinopathy Optical coherence tomography angiography Vessel density |
| url | https://doi.org/10.1038/s41598-024-85021-8 |
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