Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study
ObjectiveThis study assessed the effects of transcranial direct current stimulation (tDCS) on cue reactivity and craving for game-related cues using event-related potentials (ERPs) in internet gaming disorder (IGD) patients.MethodsAt baseline, a series of game-related and neutral pictures were shown...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1494313/full |
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| author | Sung Nyun Kim Jung-Seok Choi Minkyung Park So Young Yoo Areum Choi Ja Wook Koo Ja Wook Koo Ung Gu Kang |
| author_facet | Sung Nyun Kim Jung-Seok Choi Minkyung Park So Young Yoo Areum Choi Ja Wook Koo Ja Wook Koo Ung Gu Kang |
| author_sort | Sung Nyun Kim |
| collection | DOAJ |
| description | ObjectiveThis study assessed the effects of transcranial direct current stimulation (tDCS) on cue reactivity and craving for game-related cues using event-related potentials (ERPs) in internet gaming disorder (IGD) patients.MethodsAt baseline, a series of game-related and neutral pictures were shown to both IGD and healthy controls (HCs) while ERPs were recorded. Late positive potentials (LPP) were used to investigate cue reactivity. During intervention, IGD patients received 10 sessions (two sessions/day for 5 consecutive days, 2 mA for 20 min/session) of tDCS to the left (anode stimulation) and right (cathode) dorsolateral prefrontal cortex. Subjectively assessed craving and LPP component was analyzed before stimulation and at the 1-month follow-up after tDCS in IGD.ResultsAt baseline, patients with IGD showed higher LPP amplitudes for game-related cues in the centro-parietal and parietal regions than HCs. After 10 sessions of tDCS, increased LPP amplitudes decreased significantly at 1-month follow-up., as well as subjective craving for gaming.ConclusionThese findings suggest that neurophysiological arousal in response to game-related cues in the IGD group could be modulated by the effects of tDCS. LPP was a significant neurophysiological marker of the neuroplastic response of cue reactivity underlying the therapeutic effect of tDCS on IGD. Based on the present findings, tDCS could be expanded to the treatment of other addictive disorders, including substance use disorder and behavioral addictions. |
| format | Article |
| id | doaj-art-02c2db45e84e486a9f750500ccc8ca2c |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-02c2db45e84e486a9f750500ccc8ca2c2025-01-14T05:10:36ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.14943131494313Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential studySung Nyun Kim0Jung-Seok Choi1Minkyung Park2So Young Yoo3Areum Choi4Ja Wook Koo5Ja Wook Koo6Ung Gu Kang7Department of Psychiatry, Seoul Medical Center, Seoul, Republic of KoreaDepartment of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaEmotion, Cognition and Behavior Research Group, Korea Brain Research Institute, Daegu, Republic of KoreaDepartment of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaDepartment of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of KoreaObjectiveThis study assessed the effects of transcranial direct current stimulation (tDCS) on cue reactivity and craving for game-related cues using event-related potentials (ERPs) in internet gaming disorder (IGD) patients.MethodsAt baseline, a series of game-related and neutral pictures were shown to both IGD and healthy controls (HCs) while ERPs were recorded. Late positive potentials (LPP) were used to investigate cue reactivity. During intervention, IGD patients received 10 sessions (two sessions/day for 5 consecutive days, 2 mA for 20 min/session) of tDCS to the left (anode stimulation) and right (cathode) dorsolateral prefrontal cortex. Subjectively assessed craving and LPP component was analyzed before stimulation and at the 1-month follow-up after tDCS in IGD.ResultsAt baseline, patients with IGD showed higher LPP amplitudes for game-related cues in the centro-parietal and parietal regions than HCs. After 10 sessions of tDCS, increased LPP amplitudes decreased significantly at 1-month follow-up., as well as subjective craving for gaming.ConclusionThese findings suggest that neurophysiological arousal in response to game-related cues in the IGD group could be modulated by the effects of tDCS. LPP was a significant neurophysiological marker of the neuroplastic response of cue reactivity underlying the therapeutic effect of tDCS on IGD. Based on the present findings, tDCS could be expanded to the treatment of other addictive disorders, including substance use disorder and behavioral addictions.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1494313/fulltDCSERPcue reactivitycravinginternet gaming disorder |
| spellingShingle | Sung Nyun Kim Jung-Seok Choi Minkyung Park So Young Yoo Areum Choi Ja Wook Koo Ja Wook Koo Ung Gu Kang Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study Frontiers in Public Health tDCS ERP cue reactivity craving internet gaming disorder |
| title | Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study |
| title_full | Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study |
| title_fullStr | Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study |
| title_full_unstemmed | Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study |
| title_short | Neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder: an event-related potential study |
| title_sort | neuromodulatory effect of transcranial direct current stimulation on cue reactivity and craving in young adults with internet gaming disorder an event related potential study |
| topic | tDCS ERP cue reactivity craving internet gaming disorder |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1494313/full |
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