Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol
Introduction Male infertility, defined as the inability to impregnate a fertile female, arises from various factors, among which sperm motility plays a pivotal role in determining reproductive potential. Seminal plasma, a complex fluid comprising diverse proteins, serves to nourish and support sperm...
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| Format: | Article |
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/12/e089058.full |
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| author | Nathalie Dilhara Willathgamuwa Manodya Kaushani Nammunige Thennakoon Mudiyanselage Hiranthika Piyumali Thennakoon Nissanka Mudiyanselage Tanuri Ayanga Nissanka Manushi Dinasha Withanage Dona Nishadi Sachinthani Rodrigo Prassana Varun Logenthiran |
| author_facet | Nathalie Dilhara Willathgamuwa Manodya Kaushani Nammunige Thennakoon Mudiyanselage Hiranthika Piyumali Thennakoon Nissanka Mudiyanselage Tanuri Ayanga Nissanka Manushi Dinasha Withanage Dona Nishadi Sachinthani Rodrigo Prassana Varun Logenthiran |
| author_sort | Nathalie Dilhara Willathgamuwa |
| collection | DOAJ |
| description | Introduction Male infertility, defined as the inability to impregnate a fertile female, arises from various factors, among which sperm motility plays a pivotal role in determining reproductive potential. Seminal plasma, a complex fluid comprising diverse proteins, serves to nourish and support sperm, thereby facilitating their function within the female reproductive tract for successful conception. Normozoospermia denotes normal sperm motility in males, whereas asthenozoospermia indicates reduced sperm motility. This review seeks to assess the feasibility of augmenting sperm motility in men with asthenozoospermia through supplementation with seminal plasma or specific seminal plasma proteins.Methods and analysis A systematic literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be conducted. PubMed and Google Scholar databases will be systematically searched using predefined keywords and Boolean operators. The search strategy will encompass terms related to asthenozoospermia, normozoospermia, seminal plasma proteins, sperm motility and sperm movement. Additionally, reference lists of relevant articles will be scrutinised for additional studies. Inclusion criteria will encompass human studies published as original research articles between 2019 and 2023. Data extraction will be performed using a standardised form, encompassing author details, country of origin, publication year, study design, participant characteristics, outcomes and conclusions. The risk of bias within the selected studies will be evaluated using the Robvis visualisation tool.Ethics and dissemination Ethical approval is not required for this systematic review. The findings will be disseminated through publication in a peer-reviewed scientific journal and presentation at relevant conferences.PROSPERO registration number CRD42024526439 |
| format | Article |
| id | doaj-art-02b7d95c69444b72844c2317408b7306 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-02b7d95c69444b72844c2317408b73062025-01-01T03:30:09ZengBMJ Publishing GroupBMJ Open2044-60552024-12-01141210.1136/bmjopen-2024-089058Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocolNathalie Dilhara Willathgamuwa0Manodya Kaushani Nammunige1Thennakoon Mudiyanselage Hiranthika Piyumali Thennakoon2Nissanka Mudiyanselage Tanuri Ayanga Nissanka3Manushi Dinasha Withanage Dona4Nishadi Sachinthani Rodrigo5Prassana Varun Logenthiran6Coventry University, Coventry, UKCoventry University, Coventry, UKCoventry University, Coventry, UKCoventry University, Coventry, UKCoventry University, Coventry, UKDepartment of Anatomy, Uva Wellassa University, Badulla, Sri LankaDepartment of Physiology, University of Sri Jayewardenepura, Nugegoda, Sri LankaIntroduction Male infertility, defined as the inability to impregnate a fertile female, arises from various factors, among which sperm motility plays a pivotal role in determining reproductive potential. Seminal plasma, a complex fluid comprising diverse proteins, serves to nourish and support sperm, thereby facilitating their function within the female reproductive tract for successful conception. Normozoospermia denotes normal sperm motility in males, whereas asthenozoospermia indicates reduced sperm motility. This review seeks to assess the feasibility of augmenting sperm motility in men with asthenozoospermia through supplementation with seminal plasma or specific seminal plasma proteins.Methods and analysis A systematic literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be conducted. PubMed and Google Scholar databases will be systematically searched using predefined keywords and Boolean operators. The search strategy will encompass terms related to asthenozoospermia, normozoospermia, seminal plasma proteins, sperm motility and sperm movement. Additionally, reference lists of relevant articles will be scrutinised for additional studies. Inclusion criteria will encompass human studies published as original research articles between 2019 and 2023. Data extraction will be performed using a standardised form, encompassing author details, country of origin, publication year, study design, participant characteristics, outcomes and conclusions. The risk of bias within the selected studies will be evaluated using the Robvis visualisation tool.Ethics and dissemination Ethical approval is not required for this systematic review. The findings will be disseminated through publication in a peer-reviewed scientific journal and presentation at relevant conferences.PROSPERO registration number CRD42024526439https://bmjopen.bmj.com/content/14/12/e089058.full |
| spellingShingle | Nathalie Dilhara Willathgamuwa Manodya Kaushani Nammunige Thennakoon Mudiyanselage Hiranthika Piyumali Thennakoon Nissanka Mudiyanselage Tanuri Ayanga Nissanka Manushi Dinasha Withanage Dona Nishadi Sachinthani Rodrigo Prassana Varun Logenthiran Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol BMJ Open |
| title | Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol |
| title_full | Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol |
| title_fullStr | Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol |
| title_full_unstemmed | Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol |
| title_short | Determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia: a systematic review protocol |
| title_sort | determining the effect of seminal plasma supplementation on sperm motility in males with asthenozoospermia a systematic review protocol |
| url | https://bmjopen.bmj.com/content/14/12/e089058.full |
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