Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer

Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer

Background Anti-PD-1(L1) therapies are less efficacious in patients with EGFR-mutated non-small-cell lung cancer. However, the underlying mechanism is poorly understood.Methods The characteristics of T cells in EGFR-mutated and wild-type tumors were analyzed based on The Cancer Genome Atlas database...

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Bibliographic Details
Main Authors:	Lei Cheng, Caicun Zhou, Tao Jiang, Fei Zhou, Shengxiang Ren, Hongcheng Liu, Xinyu Liu, Xiaoxia Chen, Xuefei Li, Chao Zhao, Meng Qiao, Haowei Wang, Yijun Jia
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2022-12-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/10/12/e005436.full
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