Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice

Purpose of the study. There is the generalized analysis of administration of vinflunine in real clinical practice in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological).Materials and methods. This analysis gathered 27 patients with urothelial carcinoma tr...

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Main Authors: A. S. Zhabina, A. I. Novikov, F. V. Moiseenko, N. M. Volkov, E. O. Stepanova, E. V. Artemeva, N. H. Abduloeva, V. M. Moiseenko
Format: Article
Language:Russian
Published: QUASAR, LLC 2021-06-01
Series:Исследования и практика в медицине
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Online Access:https://www.rpmj.ru/rpmj/article/view/720
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author A. S. Zhabina
A. I. Novikov
F. V. Moiseenko
N. M. Volkov
E. O. Stepanova
E. V. Artemeva
N. H. Abduloeva
V. M. Moiseenko
author_facet A. S. Zhabina
A. I. Novikov
F. V. Moiseenko
N. M. Volkov
E. O. Stepanova
E. V. Artemeva
N. H. Abduloeva
V. M. Moiseenko
author_sort A. S. Zhabina
collection DOAJ
description Purpose of the study. There is the generalized analysis of administration of vinflunine in real clinical practice in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological).Materials and methods. This analysis gathered 27 patients with urothelial carcinoma treated using this medicine in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological). We assessed efficacy, safety profile of vinflunine in this subset of patients.Results. Clinical efficacy of vinflunine (complete response + partial response + stable disease) was 51,86 %, one patient demonstrated complete response. Median of response duration accounts for 3,4 months. Adverse events were observed in 28,4 %, most of them were 1-2 grades. 2 patients stopped therapy due to adverse events.Conclusion. In our analysis vinflunine was more effective than in randomized clinical trial and other studies from real practice in Europe. Thus, confirm expediency to administer of vinflunine for metastatic urothelial carcinoma.
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institution Kabale University
issn 2410-1893
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publishDate 2021-06-01
publisher QUASAR, LLC
record_format Article
series Исследования и практика в медицине
spelling doaj-art-02ac5742c0f54e10b12b140e137026f42025-02-03T07:12:12ZrusQUASAR, LLCИсследования и практика в медицине2410-18932021-06-0182344210.17709/2410-1893-2021-8-2-3375Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practiceA. S. Zhabina0A. I. Novikov1F. V. Moiseenko2N. M. Volkov3E. O. Stepanova4E. V. Artemeva5N. H. Abduloeva6V. M. Moiseenko7St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological); N. N.Petrov National Medical Research Center of OncologySt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological); N. N.Petrov National Medical Research Center of Oncology; North-Western State Medical University named after I. I. MechnikovSt. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)St. Petersburg Clinical Scientific and Practical Center for Specialized Types of Medical Care (Oncological)Purpose of the study. There is the generalized analysis of administration of vinflunine in real clinical practice in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological).Materials and methods. This analysis gathered 27 patients with urothelial carcinoma treated using this medicine in St.Petersburg Clinical Scientific and Practical Center of Specialized medical Care (oncological). We assessed efficacy, safety profile of vinflunine in this subset of patients.Results. Clinical efficacy of vinflunine (complete response + partial response + stable disease) was 51,86 %, one patient demonstrated complete response. Median of response duration accounts for 3,4 months. Adverse events were observed in 28,4 %, most of them were 1-2 grades. 2 patients stopped therapy due to adverse events.Conclusion. In our analysis vinflunine was more effective than in randomized clinical trial and other studies from real practice in Europe. Thus, confirm expediency to administer of vinflunine for metastatic urothelial carcinoma.https://www.rpmj.ru/rpmj/article/view/720urothelial cancervinflunineefficacysafetysurvivalbladder
spellingShingle A. S. Zhabina
A. I. Novikov
F. V. Moiseenko
N. M. Volkov
E. O. Stepanova
E. V. Artemeva
N. H. Abduloeva
V. M. Moiseenko
Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
Исследования и практика в медицине
urothelial cancer
vinflunine
efficacy
safety
survival
bladder
title Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
title_full Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
title_fullStr Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
title_full_unstemmed Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
title_short Bladder cancer. A retrospective analysis of the use of vinfluvin in real clinical practice
title_sort bladder cancer a retrospective analysis of the use of vinfluvin in real clinical practice
topic urothelial cancer
vinflunine
efficacy
safety
survival
bladder
url https://www.rpmj.ru/rpmj/article/view/720
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AT ainovikov bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT fvmoiseenko bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT nmvolkov bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT eostepanova bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT evartemeva bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT nhabduloeva bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice
AT vmmoiseenko bladdercanceraretrospectiveanalysisoftheuseofvinfluvininrealclinicalpractice