Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration

Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration

Abstract Background Autoantibodies targeting the intracellular 65-kDa isoform of glutamic acid decarboxylase (anti-GAD65) have been associated with a variety of autoimmune-related syndromes involving a spectrum of difficult-to-treat neurological disorders. However, the pathophysiological role of ant...

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Bibliographic Details
Main Authors:	Annika Breuer, Delara Kamalizade, Tobias Baumgartner, Juliane L. Berns, Thoralf Opitz, Franziska S. Thaler, Susanne Schoch, Lars Komorowski, Christoph Helmstaedter, Rainer Surges, Albert J. Becker, Julika Pitsch
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Journal of Neuroinflammation
Subjects:	Glutamate decarboxylase 65 (GAD65) Cytosolic 5'-nucleotidase 1A (CN1A) Temporal lobe epilepsy Limbic encephalitis Autoimmune encephalitis
Online Access:	https://doi.org/10.1186/s12974-025-03521-4
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