Controlled Modulation of Serum Protein Binding and Biodistribution of Asymmetric Cyanine Dyes by Variation of the Number of Sulfonate Groups

Controlled Modulation of Serum Protein Binding and Biodistribution of Asymmetric Cyanine Dyes by Variation of the Number of Sulfonate Groups

To assess the suitability of asymmetric cyanine dyes for in vivo fluoro-optical molecular imaging, a comprehensive study on the influence of the number of negatively charged sulfonate groups governing the hydrophilicity of the DY-67x family of asymmetric cyanines was performed. Special attention was...

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Bibliographic Details
Main Authors: Franziska M. Hamann, Robert Brehm, Jutta Pauli, Markus Grabolle, Wilhelm Frank, Werner A. Kaiser, Dagmar Fischer, Ute Resch-Genger, Ingrid Hilger
Format: Article
Language:English
Published: SAGE Publishing 2011-07-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2011.00005
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