Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study
Abstract The aim of this cross-sectional study was to perform a three-dimensional (3D) assessment of the cranial base of patients with unilateral cleft lip and palate (UCLP). Cone-beam computed tomography (CBCT) scans of 52 UCLP patients (21 females and 31 males; mean age, 10.0 ± 2.12 years) were co...
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Sociedade Brasileira de Pesquisa Odontológica
2025-01-01
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| Series: | Brazilian Oral Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101200&lng=en&tlng=en |
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| author | Eduardo Murad VILLORIA Bernardo Quiroga SOUKI Marina Araújo Leite ASSIS Dauro Douglas OLIVEIRA Thaís de Lima AZEREDO Rodrigo Villamarim SOARES |
| author_facet | Eduardo Murad VILLORIA Bernardo Quiroga SOUKI Marina Araújo Leite ASSIS Dauro Douglas OLIVEIRA Thaís de Lima AZEREDO Rodrigo Villamarim SOARES |
| author_sort | Eduardo Murad VILLORIA |
| collection | DOAJ |
| description | Abstract The aim of this cross-sectional study was to perform a three-dimensional (3D) assessment of the cranial base of patients with unilateral cleft lip and palate (UCLP). Cone-beam computed tomography (CBCT) scans of 52 UCLP patients (21 females and 31 males; mean age, 10.0 ± 2.12 years) were compared with the scans of 72 individuals (24 females and 48 males; mean age, 11.0 ± 2.11 years) without CLP, matched by gender and age (control group, CG). The 3D Euclidean distances of anterior cranial base (N-S), posterior cranial base (S-Ba), total cranial base (N-Ba) lengths, cranial base width (Po-Po), as well as the cranial base flexure (NSBa), were measured using open-source software ITK-SNAP and 3D Slicer. Statistical analyses were carried out with the Student’s t-test at a significance level of 5%. UCLP demonstrated shorter 3D distances than CG in the N-S, S-Ba, and N-Ba cranial base lengths (p < 0.001). In comparison with female CG, female UCLP had a smaller cranial base flexure (NSBa; p = 0.020). No statistically significant differences between UCLP and CG were found for the cranial base width (Po-Po). UCLP patients presented distinct morphological cranial base characteristics in comparison with CG. These results indicate that morphological and positioning changes in the maxillary bones are not solely attributable to the cleft and/or surgical procedures. |
| format | Article |
| id | doaj-art-023ae14d2cfb434090392dc32532e640 |
| institution | Kabale University |
| issn | 1807-3107 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj-art-023ae14d2cfb434090392dc32532e6402025-01-14T07:41:20ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072025-01-013910.1590/1807-3107bor-2025.vol39.004Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional studyEduardo Murad VILLORIAhttps://orcid.org/0000-0002-4671-3650Bernardo Quiroga SOUKIhttps://orcid.org/0000-0002-1907-9519Marina Araújo Leite ASSIShttps://orcid.org/0000-0003-3040-3160Dauro Douglas OLIVEIRAhttps://orcid.org/0000-0003-4323-0562Thaís de Lima AZEREDOhttps://orcid.org/0000-0002-7906-8918Rodrigo Villamarim SOAREShttps://orcid.org/0000-0001-7698-7532Abstract The aim of this cross-sectional study was to perform a three-dimensional (3D) assessment of the cranial base of patients with unilateral cleft lip and palate (UCLP). Cone-beam computed tomography (CBCT) scans of 52 UCLP patients (21 females and 31 males; mean age, 10.0 ± 2.12 years) were compared with the scans of 72 individuals (24 females and 48 males; mean age, 11.0 ± 2.11 years) without CLP, matched by gender and age (control group, CG). The 3D Euclidean distances of anterior cranial base (N-S), posterior cranial base (S-Ba), total cranial base (N-Ba) lengths, cranial base width (Po-Po), as well as the cranial base flexure (NSBa), were measured using open-source software ITK-SNAP and 3D Slicer. Statistical analyses were carried out with the Student’s t-test at a significance level of 5%. UCLP demonstrated shorter 3D distances than CG in the N-S, S-Ba, and N-Ba cranial base lengths (p < 0.001). In comparison with female CG, female UCLP had a smaller cranial base flexure (NSBa; p = 0.020). No statistically significant differences between UCLP and CG were found for the cranial base width (Po-Po). UCLP patients presented distinct morphological cranial base characteristics in comparison with CG. These results indicate that morphological and positioning changes in the maxillary bones are not solely attributable to the cleft and/or surgical procedures.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101200&lng=en&tlng=enCleft LipCleft PalateSkull BaseCone-Beam Computed Tomography |
| spellingShingle | Eduardo Murad VILLORIA Bernardo Quiroga SOUKI Marina Araújo Leite ASSIS Dauro Douglas OLIVEIRA Thaís de Lima AZEREDO Rodrigo Villamarim SOARES Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study Brazilian Oral Research Cleft Lip Cleft Palate Skull Base Cone-Beam Computed Tomography |
| title | Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study |
| title_full | Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study |
| title_fullStr | Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study |
| title_full_unstemmed | Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study |
| title_short | Unilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study |
| title_sort | unilateral cleft lip and palate patients present cranial base modifications a cross sectional study |
| topic | Cleft Lip Cleft Palate Skull Base Cone-Beam Computed Tomography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101200&lng=en&tlng=en |
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