Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis

Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis

Abstract Pyroptosis, a programmed form of cell death, typically increases during the atherosclerosis development. Cyclodextrins are oligosaccharides with anti-atherosclerotic properties. Therefore, the present study aims to explore the role of methyl-ß-cyclodextrin (Mß-CD), a representative of cyclo...

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Bibliographic Details
Main Authors: Mohammad Ismail Hajary Sagor, Qiuran Wang, Junshu Wang, Guili Lian, Yan Yan, Huibin Tang, Gufeng Gao, Huakan Lin, Liangdi Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Atherosclerosis
NLRP3 inflammasome
GSDMD-NT
ox-LDL
Pyroptosis
Methyl-ß-cyclodextrin
Online Access:https://doi.org/10.1038/s41598-025-04889-2
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