Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis
ObjectiveTo investigate the characteristics and risk factors of acute febrile reaction after zoledronic acid treatment for primary osteoporosis.MethodsA total of 517 patients diagnosed with primary osteoporosis and treated with zoledronic acid from January 2012 to December 2020 were recruited, inclu...
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Editorial Office of Rehabilitation Medicine
2022-06-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2022.03002 |
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| author | WU Hongliang ZHENG Sihang ZHANG Enchong HOSSAIN Mohammad Showkat GONG Helong XING Ruida JING Shengjie LI Yan |
| author_facet | WU Hongliang ZHENG Sihang ZHANG Enchong HOSSAIN Mohammad Showkat GONG Helong XING Ruida JING Shengjie LI Yan |
| author_sort | WU Hongliang |
| collection | DOAJ |
| description | ObjectiveTo investigate the characteristics and risk factors of acute febrile reaction after zoledronic acid treatment for primary osteoporosis.MethodsA total of 517 patients diagnosed with primary osteoporosis and treated with zoledronic acid from January 2012 to December 2020 were recruited, including 40 males and 477 females, among whom 262 were with type Ⅰ osteoporosis and 255 were with type Ⅱ osteoposis, 245 patients with mild-to-moderate osteoporosis, 272 patients with severe osteoporosis, 230 patients with fresh fracture, and 209 patients with operation. The two groups were compared, and the fever rate and clinical characteristics of fever were summarized and further analyzed in the aspects of gender, age, count of white blood cells, neutrophils, lymphocytes, neutrophil-lymphocyte ratio (NLR), type of osteoporosis, degree of osteoporosis, fracture, surgery intervention, medication history, etc. Multivariate <italic>Logistic</italic> regression analysis was conducted and ROC curve was drawn to explore the main risk factors for acute febrile reaction.ResultsThe 175 cases (33.85%) developed acute febrile reaction, most of which occurred within 36 hours after treatment, mainly low and moderate fever (<39 ℃), and the duration was generally no more than 60 hours. Univariate analysis showed significant differences in NLR, type and degree of osteoporosis, fresh fracture, surgery intervention, and zoledronic acid medication history between the fever and non-fever groups (<italic>P</italic><0.05). There was no significant difference in gender, count of white blood cells, neutrophils and lymphocytes between the two groups (<italic>P</italic>>0.05). <italic>Logistic</italic> regression and ROC curve analysis showed that the surgery group had a higher fever rate (<italic>P</italic><0.01, area under ROC curve was 0.65). The fracture group had a higher fever rate (<italic>P</italic><0.05, area under ROC curve was 0.60). The group with type Ⅰ osteoporosis had a higher fever rate (<italic>P</italic><0.01, area under ROC curve was 0.44). The group with medication history had a lower fever rate (<italic>P</italic><0.01, area under ROC curve was 0.34). The fever rate of joint fracture group (56.60%) was significantly higher than spine fracture group (38.54%) (<italic>P</italic><0.05).ConclusionSurgery, fracture, type Ⅰ osteoporosis and first zoledronic acid medication might be independent risk factors of acute febrile reaction after medication. Patients who had surgery before medication (especially those with joint fracture surgery), fresh fracture, type Ⅰ osteoporosis and first zoledronic acid medication, had a higher risk of acute febrile reaction. |
| format | Article |
| id | doaj-art-02141087f66e43a0a61b2f2163f1e7ab |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
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| series | 康复学报 |
| spelling | doaj-art-02141087f66e43a0a61b2f2163f1e7ab2025-01-14T10:07:53ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282022-06-013219720528090624Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary OsteoporosisWU HongliangZHENG SihangZHANG EnchongHOSSAIN Mohammad ShowkatGONG HelongXING RuidaJING ShengjieLI YanObjectiveTo investigate the characteristics and risk factors of acute febrile reaction after zoledronic acid treatment for primary osteoporosis.MethodsA total of 517 patients diagnosed with primary osteoporosis and treated with zoledronic acid from January 2012 to December 2020 were recruited, including 40 males and 477 females, among whom 262 were with type Ⅰ osteoporosis and 255 were with type Ⅱ osteoposis, 245 patients with mild-to-moderate osteoporosis, 272 patients with severe osteoporosis, 230 patients with fresh fracture, and 209 patients with operation. The two groups were compared, and the fever rate and clinical characteristics of fever were summarized and further analyzed in the aspects of gender, age, count of white blood cells, neutrophils, lymphocytes, neutrophil-lymphocyte ratio (NLR), type of osteoporosis, degree of osteoporosis, fracture, surgery intervention, medication history, etc. Multivariate <italic>Logistic</italic> regression analysis was conducted and ROC curve was drawn to explore the main risk factors for acute febrile reaction.ResultsThe 175 cases (33.85%) developed acute febrile reaction, most of which occurred within 36 hours after treatment, mainly low and moderate fever (<39 ℃), and the duration was generally no more than 60 hours. Univariate analysis showed significant differences in NLR, type and degree of osteoporosis, fresh fracture, surgery intervention, and zoledronic acid medication history between the fever and non-fever groups (<italic>P</italic><0.05). There was no significant difference in gender, count of white blood cells, neutrophils and lymphocytes between the two groups (<italic>P</italic>>0.05). <italic>Logistic</italic> regression and ROC curve analysis showed that the surgery group had a higher fever rate (<italic>P</italic><0.01, area under ROC curve was 0.65). The fracture group had a higher fever rate (<italic>P</italic><0.05, area under ROC curve was 0.60). The group with type Ⅰ osteoporosis had a higher fever rate (<italic>P</italic><0.01, area under ROC curve was 0.44). The group with medication history had a lower fever rate (<italic>P</italic><0.01, area under ROC curve was 0.34). The fever rate of joint fracture group (56.60%) was significantly higher than spine fracture group (38.54%) (<italic>P</italic><0.05).ConclusionSurgery, fracture, type Ⅰ osteoporosis and first zoledronic acid medication might be independent risk factors of acute febrile reaction after medication. Patients who had surgery before medication (especially those with joint fracture surgery), fresh fracture, type Ⅰ osteoporosis and first zoledronic acid medication, had a higher risk of acute febrile reaction.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2022.03002primary osteoporosiszoledronic acidacute febrile reactionsurgeryfracturetype of osteoporosis |
| spellingShingle | WU Hongliang ZHENG Sihang ZHANG Enchong HOSSAIN Mohammad Showkat GONG Helong XING Ruida JING Shengjie LI Yan Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis 康复学报 primary osteoporosis zoledronic acid acute febrile reaction surgery fracture type of osteoporosis |
| title | Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis |
| title_full | Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis |
| title_fullStr | Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis |
| title_full_unstemmed | Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis |
| title_short | Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis |
| title_sort | risk factors for acute febrile reaction after zoledronic acid treatment for primary osteoporosis |
| topic | primary osteoporosis zoledronic acid acute febrile reaction surgery fracture type of osteoporosis |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2022.03002 |
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