Review of 20-year results of ASCOT Legacy
The article presents the results of a 20-year follow-up of patients in the ASCOT Legacy study, indicating that antihypertensive and lipid-lowering therapy reduces mortality in patients with hypertension and high cardiovascular risk in the long term. In the group of patients treated with amlodipine c...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2023-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5457 |
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| _version_ | 1849250049033240576 |
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| author | M. B. Nagorny A. N. Kuchmin |
| author_facet | M. B. Nagorny A. N. Kuchmin |
| author_sort | M. B. Nagorny |
| collection | DOAJ |
| description | The article presents the results of a 20-year follow-up of patients in the ASCOT Legacy study, indicating that antihypertensive and lipid-lowering therapy reduces mortality in patients with hypertension and high cardiovascular risk in the long term. In the group of patients treated with amlodipine compared with the β-blocker atenolol, there was a decrease in mean systolic and diastolic blood pressure (BP), as well as a long-term improve in the form of a decrease in the prevalence of cardiovascular events and mortality due to stroke. An important feature of therapy based on amlodipine was the reduction in BP variability. The article reflects the results of major studies that determine the possibility and effectiveness of early prescription of combined antihypertensive and lipid-lowering therapy. |
| format | Article |
| id | doaj-art-01fba244afda4e8b85afa82a134ae49a |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-01fba244afda4e8b85afa82a134ae49a2025-08-20T03:57:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-06-0128510.15829/1560-4071-2023-54573826Review of 20-year results of ASCOT LegacyM. B. Nagorny0A. N. Kuchmin1S. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyThe article presents the results of a 20-year follow-up of patients in the ASCOT Legacy study, indicating that antihypertensive and lipid-lowering therapy reduces mortality in patients with hypertension and high cardiovascular risk in the long term. In the group of patients treated with amlodipine compared with the β-blocker atenolol, there was a decrease in mean systolic and diastolic blood pressure (BP), as well as a long-term improve in the form of a decrease in the prevalence of cardiovascular events and mortality due to stroke. An important feature of therapy based on amlodipine was the reduction in BP variability. The article reflects the results of major studies that determine the possibility and effectiveness of early prescription of combined antihypertensive and lipid-lowering therapy.https://russjcardiol.elpub.ru/jour/article/view/5457amlodipinehypertensionblood pressureblood pressure variabilitycardiovascular riskperindoprilfixed-dose combinations |
| spellingShingle | M. B. Nagorny A. N. Kuchmin Review of 20-year results of ASCOT Legacy Российский кардиологический журнал amlodipine hypertension blood pressure blood pressure variability cardiovascular risk perindopril fixed-dose combinations |
| title | Review of 20-year results of ASCOT Legacy |
| title_full | Review of 20-year results of ASCOT Legacy |
| title_fullStr | Review of 20-year results of ASCOT Legacy |
| title_full_unstemmed | Review of 20-year results of ASCOT Legacy |
| title_short | Review of 20-year results of ASCOT Legacy |
| title_sort | review of 20 year results of ascot legacy |
| topic | amlodipine hypertension blood pressure blood pressure variability cardiovascular risk perindopril fixed-dose combinations |
| url | https://russjcardiol.elpub.ru/jour/article/view/5457 |
| work_keys_str_mv | AT mbnagorny reviewof20yearresultsofascotlegacy AT ankuchmin reviewof20yearresultsofascotlegacy |