Hypoxia‐Mimicking Mediated Macrophage‐Elimination of Erythrocytes Promotes Bone Regeneration via Regulating Integrin αvβ3/Fe2+‐Glycolysis‐Inflammation

Hypoxia‐Mimicking Mediated Macrophage‐Elimination of Erythrocytes Promotes Bone Regeneration via Regulating Integrin αvβ3/Fe2+‐Glycolysis‐Inflammation

Abstract Erythrocytes are the dominant component of a blood clot in terms of volume and number. However, longstanding compacted erythrocytes in blood clots form a physical barrier and make fibrin mesh more anti‐fibrinolytic, thus impeding infiltration of mesenchymal stem cells. The necrosis or lysis...

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Bibliographic Details
Main Authors: Yong Ao, Yuanlong Guo, Yingye Zhang, Lv Xie, Ruidi Xia, Jieyun Xu, Mengru Shi, Xiaomeng Gao, Xiaoran Yu, Zetao Chen
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
bone regeneration
erythrocyte clearance
hypoxia‐mimicking
inflammatory responses
macrophage phagocytosis
Online Access:https://doi.org/10.1002/advs.202403921
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https://doi.org/10.1002/advs.202403921

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