A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors

A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors

Summary: Inflammasomes are protein complexes that mediate innate immune responses whose dysregulation has been linked to a spectrum of acute and chronic human conditions, which dictates therapeutic development that is aligned with disease variability. We designed a scalable, physiologic high-content...

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Bibliographic Details
Main Authors: Daniel Chen, Tempest Plott, Michael Wiest, Will Van Trump, Ben Komalo, Dat Nguyen, Charlie Marsh, Jarred Heinrich, Colin J. Fuller, Lauren Nicolaisen, Elisa Cambronero, An Nguyen, Christian Elabd, Francesco Rubbo, Rachel DeVay Jacobson
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Cell biology
Data analysis
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026294
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