The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India
Background: Sickle cell disease (SCD), thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency are significant genetic disorders prevalent in Central India, particularly among tribal populations. Early detection through the neonatal screening can improve health outcomes. Aim and Objecti...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1397_24 |
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| author | Rakesh K. Jha Meghali Kaple Ranjit S. Ambad Archana Dhok Ashsish Anjankar |
| author_facet | Rakesh K. Jha Meghali Kaple Ranjit S. Ambad Archana Dhok Ashsish Anjankar |
| author_sort | Rakesh K. Jha |
| collection | DOAJ |
| description | Background:
Sickle cell disease (SCD), thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency are significant genetic disorders prevalent in Central India, particularly among tribal populations. Early detection through the neonatal screening can improve health outcomes.
Aim and Objective:
This study aims to assess the prevalence of SCD, thalassemia, and G6PD deficiency in a cohort of newborns from tribal regions in Central India and to evaluate the effectiveness of neonatal screening programs.
Materials and Methods:
A total of 382 newborns were screened using high-performance liquid chromatography (HPLC) for hemoglobinopathies and a colorimetric method for G6PD deficiency. Data on demographics and family history were collected and analyzed.
Results:
The screening revealed 22 cases of SCD (5.8%), 37 cases of thalassemia (9.7%), and 29 cases of G6PD deficiency (7.6%). A significant correlation was found between family history and the prevalence of these disorders.
Conclusion:
The findings highlight the need for comprehensive neonatal screening programs in tribal populations to enhance early detection and management of genetic disorders. |
| format | Article |
| id | doaj-art-01c8c13fd7494100850ba2edcb3505ca |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-01c8c13fd7494100850ba2edcb3505ca2025-01-13T10:56:22ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4026S402910.4103/jpbs.jpbs_1397_24The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central IndiaRakesh K. JhaMeghali KapleRanjit S. AmbadArchana DhokAshsish AnjankarBackground: Sickle cell disease (SCD), thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency are significant genetic disorders prevalent in Central India, particularly among tribal populations. Early detection through the neonatal screening can improve health outcomes. Aim and Objective: This study aims to assess the prevalence of SCD, thalassemia, and G6PD deficiency in a cohort of newborns from tribal regions in Central India and to evaluate the effectiveness of neonatal screening programs. Materials and Methods: A total of 382 newborns were screened using high-performance liquid chromatography (HPLC) for hemoglobinopathies and a colorimetric method for G6PD deficiency. Data on demographics and family history were collected and analyzed. Results: The screening revealed 22 cases of SCD (5.8%), 37 cases of thalassemia (9.7%), and 29 cases of G6PD deficiency (7.6%). A significant correlation was found between family history and the prevalence of these disorders. Conclusion: The findings highlight the need for comprehensive neonatal screening programs in tribal populations to enhance early detection and management of genetic disorders.https://journals.lww.com/10.4103/jpbs.jpbs_1397_24g6pd deficiencyneonatal screeningsickle cell diseasethalassemiatribal populations |
| spellingShingle | Rakesh K. Jha Meghali Kaple Ranjit S. Ambad Archana Dhok Ashsish Anjankar The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India Journal of Pharmacy and Bioallied Sciences g6pd deficiency neonatal screening sickle cell disease thalassemia tribal populations |
| title | The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India |
| title_full | The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India |
| title_fullStr | The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India |
| title_full_unstemmed | The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India |
| title_short | The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India |
| title_sort | neonatal screening for sickle cell disease thalassemia and g6pd deficiency in central india |
| topic | g6pd deficiency neonatal screening sickle cell disease thalassemia tribal populations |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1397_24 |
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