Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life
<b>Background/Objectives</b>: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. <b>Methods</b...
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2024-11-01
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| author | Aida M. S. Salem Takwa Mohamed AbdEltwwab Hanan Hosni Moawad Marwa O. Elgendy Reham S. Al-Fakharany Ahmed Khames Mohamed Hussein Meabed |
| author_facet | Aida M. S. Salem Takwa Mohamed AbdEltwwab Hanan Hosni Moawad Marwa O. Elgendy Reham S. Al-Fakharany Ahmed Khames Mohamed Hussein Meabed |
| author_sort | Aida M. S. Salem |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. <b>Methods</b>: This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals. <b>Results</b>: Serum vitamin D levels were significantly lower in hemophilia A patients than in controls (<i>p</i> < 0.001). The level of serum vitamin D was deficient in 38 (84.4%), insufficient in 4 (8.8%) and sufficient in 3 (6.6%) in the study group while deficient in 8 (17.7%), insufficient in 16 (35.5%) and sufficient in 21 (46.6%) in the control group. Total hemophilia joint health score (HJHS) had a significant negative correlation with serum total calcium (R = −0.31, <i>p</i> = 0.038) and serum vitamin D level (R = −0.974, <i>p</i> < 0.001) while also positively correlated with alkaline phosphatase (R = 0.834, <i>p</i> < 0.001). A quality-of-life index that is specific to total hemophilia (Haemo-Qol/Haem-A-QoL) had a significant positive correlation with total hemophilia joint health score (HJHS) (R = 0.934, <i>p</i> < 0.001) and negatively correlated with serum vitamin D level (R = −0.924, <i>p</i>-value lower than 0.001), alkaline phosphatase (R = 0.842, <i>p</i> < 0.001), and severity of hemophilia (R = 0.67, <i>p</i> < 0.001). <b>Conclusions</b>: patients with hemophilia A had lower vitamin D levels than healthy controls. The severity of vitamin D deficiency is related positively to (HJHS) hemophilia and quality of life hemophilia cases according to Haemo-QoL. |
| format | Article |
| id | doaj-art-01a109f7d16749a9b4c2a8918a0c39c9 |
| institution | Kabale University |
| issn | 2038-8330 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Hematology Reports |
| spelling | doaj-art-01a109f7d16749a9b4c2a8918a0c39c92024-12-27T14:28:43ZengMDPI AGHematology Reports2038-83302024-11-0116474275110.3390/hematolrep16040071Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of LifeAida M. S. Salem0Takwa Mohamed AbdEltwwab1Hanan Hosni Moawad2Marwa O. Elgendy3Reham S. Al-Fakharany4Ahmed Khames5Mohamed Hussein Meabed6Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, EgyptDepartment of Pediatrics, General Authority for Health Insurance, Beni-Suef 62511, EgyptDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, EgyptDepartment of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, EgyptDepartment of Medical Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21944, Saudi ArabiaDepartment of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt<b>Background/Objectives</b>: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. <b>Methods</b>: This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals. <b>Results</b>: Serum vitamin D levels were significantly lower in hemophilia A patients than in controls (<i>p</i> < 0.001). The level of serum vitamin D was deficient in 38 (84.4%), insufficient in 4 (8.8%) and sufficient in 3 (6.6%) in the study group while deficient in 8 (17.7%), insufficient in 16 (35.5%) and sufficient in 21 (46.6%) in the control group. Total hemophilia joint health score (HJHS) had a significant negative correlation with serum total calcium (R = −0.31, <i>p</i> = 0.038) and serum vitamin D level (R = −0.974, <i>p</i> < 0.001) while also positively correlated with alkaline phosphatase (R = 0.834, <i>p</i> < 0.001). A quality-of-life index that is specific to total hemophilia (Haemo-Qol/Haem-A-QoL) had a significant positive correlation with total hemophilia joint health score (HJHS) (R = 0.934, <i>p</i> < 0.001) and negatively correlated with serum vitamin D level (R = −0.924, <i>p</i>-value lower than 0.001), alkaline phosphatase (R = 0.842, <i>p</i> < 0.001), and severity of hemophilia (R = 0.67, <i>p</i> < 0.001). <b>Conclusions</b>: patients with hemophilia A had lower vitamin D levels than healthy controls. The severity of vitamin D deficiency is related positively to (HJHS) hemophilia and quality of life hemophilia cases according to Haemo-QoL.https://www.mdpi.com/2038-8330/16/4/71hemophilia Avitamin DHJHSHaemo-Qol |
| spellingShingle | Aida M. S. Salem Takwa Mohamed AbdEltwwab Hanan Hosni Moawad Marwa O. Elgendy Reham S. Al-Fakharany Ahmed Khames Mohamed Hussein Meabed Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life Hematology Reports hemophilia A vitamin D HJHS Haemo-Qol |
| title | Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life |
| title_full | Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life |
| title_fullStr | Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life |
| title_full_unstemmed | Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life |
| title_short | Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life |
| title_sort | serum vitamin d in children with hemophilia a and its association with joint health and quality of life |
| topic | hemophilia A vitamin D HJHS Haemo-Qol |
| url | https://www.mdpi.com/2038-8330/16/4/71 |
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