Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report
Sacrococcygeal teratomas (SCTs) are rare in adults, and malignant transformation within these tumors is exceedingly uncommon. The risk of malignant transformation among adults can vary between 1% and 12% and increases over time with the endopelvic location. Here, we present a case of invasive adenoc...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/crip/5088951 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849330857701015552 |
|---|---|
| author | Yasamin Mirzabeigi Clara Milikowski |
| author_facet | Yasamin Mirzabeigi Clara Milikowski |
| author_sort | Yasamin Mirzabeigi |
| collection | DOAJ |
| description | Sacrococcygeal teratomas (SCTs) are rare in adults, and malignant transformation within these tumors is exceedingly uncommon. The risk of malignant transformation among adults can vary between 1% and 12% and increases over time with the endopelvic location. Here, we present a case of invasive adenocarcinoma with intestinal and pancreatobiliary features arising from a preexisting SCT in a 64-year-old female. The patient presented with a rapidly enlarging sacral mass and purulent drainage decades after the excision of a congenital lump in the sacral region. Imaging revealed a lytic lesion involving the coccyx and sacrum, accompanied by an ill-defined soft tissue mass. Histological evaluation confirmed adenocarcinoma with dual intestinal and pancreatobiliary differentiation originating from a preexisting SCT with focal involvement of the resection margin. Postoperatively, a multidisciplinary team recommended FOLFIRINOX chemotherapy followed by completion excision surgery. This case contributes to the limited literature on adult SCTs with malignant transformation, highlighting the critical need for timely and comprehensive management. Multidisciplinary evaluation, complete surgical resection, and tailored adjuvant therapy are essential to improving patient outcomes in such rare cases. |
| format | Article |
| id | doaj-art-019ff6ef6da342fa91c1e3ef4df6b0b6 |
| institution | Kabale University |
| issn | 2090-679X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-019ff6ef6da342fa91c1e3ef4df6b0b62025-08-20T03:46:47ZengWileyCase Reports in Pathology2090-679X2025-01-01202510.1155/crip/5088951Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case ReportYasamin Mirzabeigi0Clara Milikowski1Department of Pathology and Laboratory MedicineDepartment of Pathology and Laboratory MedicineSacrococcygeal teratomas (SCTs) are rare in adults, and malignant transformation within these tumors is exceedingly uncommon. The risk of malignant transformation among adults can vary between 1% and 12% and increases over time with the endopelvic location. Here, we present a case of invasive adenocarcinoma with intestinal and pancreatobiliary features arising from a preexisting SCT in a 64-year-old female. The patient presented with a rapidly enlarging sacral mass and purulent drainage decades after the excision of a congenital lump in the sacral region. Imaging revealed a lytic lesion involving the coccyx and sacrum, accompanied by an ill-defined soft tissue mass. Histological evaluation confirmed adenocarcinoma with dual intestinal and pancreatobiliary differentiation originating from a preexisting SCT with focal involvement of the resection margin. Postoperatively, a multidisciplinary team recommended FOLFIRINOX chemotherapy followed by completion excision surgery. This case contributes to the limited literature on adult SCTs with malignant transformation, highlighting the critical need for timely and comprehensive management. Multidisciplinary evaluation, complete surgical resection, and tailored adjuvant therapy are essential to improving patient outcomes in such rare cases.http://dx.doi.org/10.1155/crip/5088951 |
| spellingShingle | Yasamin Mirzabeigi Clara Milikowski Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report Case Reports in Pathology |
| title | Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report |
| title_full | Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report |
| title_fullStr | Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report |
| title_full_unstemmed | Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report |
| title_short | Adenocarcinoma With Intestinal and Pancreatobiliary Features Arising From a Sacrococcygeal Teratoma in an Adult Female: A Case Report |
| title_sort | adenocarcinoma with intestinal and pancreatobiliary features arising from a sacrococcygeal teratoma in an adult female a case report |
| url | http://dx.doi.org/10.1155/crip/5088951 |
| work_keys_str_mv | AT yasaminmirzabeigi adenocarcinomawithintestinalandpancreatobiliaryfeaturesarisingfromasacrococcygealteratomainanadultfemaleacasereport AT claramilikowski adenocarcinomawithintestinalandpancreatobiliaryfeaturesarisingfromasacrococcygealteratomainanadultfemaleacasereport |