Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid
Recently, nanomaterials including alumina have been extensively involved in aquaculture for many purposes resulting in potential hazards in fish. However, its effect on the developing metabolic organs and lipid metabolism remains unclear. This study, investigated the effects of aluminium nanoparticl...
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Elsevier
2024-12-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513424005775 |
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| author | Suzan Attia Mawed Mervat H. Ghoneim Mayada R. Farag Marwa S.H. Abdelmoety Tamer Ahmed Ismail Sheren A. Al-Zahaby |
| author_facet | Suzan Attia Mawed Mervat H. Ghoneim Mayada R. Farag Marwa S.H. Abdelmoety Tamer Ahmed Ismail Sheren A. Al-Zahaby |
| author_sort | Suzan Attia Mawed |
| collection | DOAJ |
| description | Recently, nanomaterials including alumina have been extensively involved in aquaculture for many purposes resulting in potential hazards in fish. However, its effect on the developing metabolic organs and lipid metabolism remains unclear. This study, investigated the effects of aluminium nanoparticles (AL-NPs) on the metabolic organs of the growing zebrafish larvae including intestine, liver, and pancreas in addition to the potential ameliorative role of rosmarinic acid (RA) against AL-NPs - induced toxicity. Briefly, fertilized zebrafish eggs were divided into 4 groups. The 1st group was kept as a control. The 2nd group was exposed to RA (0.5 mg/L). The 3rd group was exposed to AL-NPs (160 mg/L). The 4th group received both RA and AL-NPs at the same concentrations from 1st day post fertilization (dpf) till the 14th dpf. Here, AL-NPs exposed group showed the highest mortality rate, external morphology defects and gastrointestinal malformations after larval-to-juvenile transition. Interestingly, mixing RA to AL-NPs significantly reduced these effects. Additionally, AL-NPs induced intestinal epithelium defects at the histological and genetic levels and abnormal lipid retention via up-regulation of the lipogenesis-related genes and down-regulation of the hepatic fatty acid β-oxidation. However, addition of RA to AL-NPs could reverse these effects. AL-NPs also induce inflammatory response and mediated endoplasmic reticulum ER and cellular oxidative stress indicated by qRT-PCR and western blot analysis which were then be reduced by RA. Collectively, AL-NPs were highly correlated with the induction of steatohepatitis and lipogenesis after the larval-to-juvenile transition and this could be relief in the presence of RA suggesting it as a promising nutrient for fish. |
| format | Article |
| id | doaj-art-01802a2f4f324638b051ebb7b6948c53 |
| institution | Kabale University |
| issn | 2352-5134 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj-art-01802a2f4f324638b051ebb7b6948c532024-12-03T04:29:27ZengElsevierAquaculture Reports2352-51342024-12-0139102489Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acidSuzan Attia Mawed0Mervat H. Ghoneim1Mayada R. Farag2Marwa S.H. Abdelmoety3Tamer Ahmed Ismail4Sheren A. Al-Zahaby5Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, EgyptForensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, EgyptForensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt; Corresponding author.Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, EgyptDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, Taif 21944, Saudi ArabiaZoology Department, Faculty of Science, Zagazig University, Zagazig 44519, EgyptRecently, nanomaterials including alumina have been extensively involved in aquaculture for many purposes resulting in potential hazards in fish. However, its effect on the developing metabolic organs and lipid metabolism remains unclear. This study, investigated the effects of aluminium nanoparticles (AL-NPs) on the metabolic organs of the growing zebrafish larvae including intestine, liver, and pancreas in addition to the potential ameliorative role of rosmarinic acid (RA) against AL-NPs - induced toxicity. Briefly, fertilized zebrafish eggs were divided into 4 groups. The 1st group was kept as a control. The 2nd group was exposed to RA (0.5 mg/L). The 3rd group was exposed to AL-NPs (160 mg/L). The 4th group received both RA and AL-NPs at the same concentrations from 1st day post fertilization (dpf) till the 14th dpf. Here, AL-NPs exposed group showed the highest mortality rate, external morphology defects and gastrointestinal malformations after larval-to-juvenile transition. Interestingly, mixing RA to AL-NPs significantly reduced these effects. Additionally, AL-NPs induced intestinal epithelium defects at the histological and genetic levels and abnormal lipid retention via up-regulation of the lipogenesis-related genes and down-regulation of the hepatic fatty acid β-oxidation. However, addition of RA to AL-NPs could reverse these effects. AL-NPs also induce inflammatory response and mediated endoplasmic reticulum ER and cellular oxidative stress indicated by qRT-PCR and western blot analysis which were then be reduced by RA. Collectively, AL-NPs were highly correlated with the induction of steatohepatitis and lipogenesis after the larval-to-juvenile transition and this could be relief in the presence of RA suggesting it as a promising nutrient for fish.http://www.sciencedirect.com/science/article/pii/S2352513424005775Aluminum nanoparticlesRosmarinic acidLipid metabolismZebrafish larvae |
| spellingShingle | Suzan Attia Mawed Mervat H. Ghoneim Mayada R. Farag Marwa S.H. Abdelmoety Tamer Ahmed Ismail Sheren A. Al-Zahaby Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid Aquaculture Reports Aluminum nanoparticles Rosmarinic acid Lipid metabolism Zebrafish larvae |
| title | Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid |
| title_full | Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid |
| title_fullStr | Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid |
| title_full_unstemmed | Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid |
| title_short | Aluminium nanoparticles (AL-NPs) caused gastrointestinal malformations, metabolic disorders and steatohepatitis in zebrafish larvae: Modulatory role of rosmarinic acid |
| title_sort | aluminium nanoparticles al nps caused gastrointestinal malformations metabolic disorders and steatohepatitis in zebrafish larvae modulatory role of rosmarinic acid |
| topic | Aluminum nanoparticles Rosmarinic acid Lipid metabolism Zebrafish larvae |
| url | http://www.sciencedirect.com/science/article/pii/S2352513424005775 |
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