Hyperuricemia, use of antituberculosis drugs, and liver injury: case report
Anti-tuberculous drug can cause idiosyncratic drug-induced liver injury (DILI). Considering the benefit risk, there will discontinuation therapy and rechallenge after symptom resolve. In addition to anti-tuberculosis drugs, liver injury can occur in patients with hyperuricemia. We report a 60-year-o...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2023-08-01
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| Series: | Jurnal Teknologi Laboratorium |
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| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/445 |
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| author | Vina Yuwantari Nur Oktafiyani Nurmelinda Hadi Ningrum M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Setiadi Marisca Evalina Gondokesumo |
| author_facet | Vina Yuwantari Nur Oktafiyani Nurmelinda Hadi Ningrum M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Setiadi Marisca Evalina Gondokesumo |
| author_sort | Vina Yuwantari |
| collection | DOAJ |
| description | Anti-tuberculous drug can cause idiosyncratic drug-induced liver injury (DILI). Considering the benefit risk, there will discontinuation therapy and rechallenge after symptom resolve. In addition to anti-tuberculosis drugs, liver injury can occur in patients with hyperuricemia. We report a 60-year-old male patient who had just used the initiation phase of OAT for 20 days experiencing hepatotoxic side effects characterized by complaints of nausea and vomiting for one week. Liver function examination results were normal with AST 23 u/L and ALT 9 u/L. OAT administration was temporarily stopped and started gradually with 150 mg rifampicin, 150 mg isoniazid and 500 mg ethambutol. The second day after using OAT again, given the full dose of 300 mg rifampicin, 300 mg isoniazid and 1000 mg ethambutol. The patient's condition improved after this modification of therapy so that therapy with three anti-TB drugs was continued until he was discharged from the hospital. |
| format | Article |
| id | doaj-art-01788e89997542b3a54bfb5fe4c91cae |
| institution | Kabale University |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| publishDate | 2023-08-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj-art-01788e89997542b3a54bfb5fe4c91cae2025-01-03T15:40:13ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912023-08-01121404510.29238/teknolabjournal.v12i1.445397Hyperuricemia, use of antituberculosis drugs, and liver injury: case reportVina Yuwantari0Nur Oktafiyani1Nurmelinda Hadi Ningrum2M. Hari Pristantiningtyas3Herya Putra Dharma4Muhammad Muchlis5Jainuri Erik Pratama6Fauna Herawati7Adji Prayitno Setiadi8Marisca Evalina Gondokesumo9University of SurabayaMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalDr. Kariadi Central General HospitalUniversity of SurabayaUniversity of SurabayaUniversitas SurabayaAnti-tuberculous drug can cause idiosyncratic drug-induced liver injury (DILI). Considering the benefit risk, there will discontinuation therapy and rechallenge after symptom resolve. In addition to anti-tuberculosis drugs, liver injury can occur in patients with hyperuricemia. We report a 60-year-old male patient who had just used the initiation phase of OAT for 20 days experiencing hepatotoxic side effects characterized by complaints of nausea and vomiting for one week. Liver function examination results were normal with AST 23 u/L and ALT 9 u/L. OAT administration was temporarily stopped and started gradually with 150 mg rifampicin, 150 mg isoniazid and 500 mg ethambutol. The second day after using OAT again, given the full dose of 300 mg rifampicin, 300 mg isoniazid and 1000 mg ethambutol. The patient's condition improved after this modification of therapy so that therapy with three anti-TB drugs was continued until he was discharged from the hospital.https://teknolabjournal.com/index.php/Jtl/article/view/445adverse effectantituberculosisdrug induced liver injury |
| spellingShingle | Vina Yuwantari Nur Oktafiyani Nurmelinda Hadi Ningrum M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Setiadi Marisca Evalina Gondokesumo Hyperuricemia, use of antituberculosis drugs, and liver injury: case report Jurnal Teknologi Laboratorium adverse effect antituberculosis drug induced liver injury |
| title | Hyperuricemia, use of antituberculosis drugs, and liver injury: case report |
| title_full | Hyperuricemia, use of antituberculosis drugs, and liver injury: case report |
| title_fullStr | Hyperuricemia, use of antituberculosis drugs, and liver injury: case report |
| title_full_unstemmed | Hyperuricemia, use of antituberculosis drugs, and liver injury: case report |
| title_short | Hyperuricemia, use of antituberculosis drugs, and liver injury: case report |
| title_sort | hyperuricemia use of antituberculosis drugs and liver injury case report |
| topic | adverse effect antituberculosis drug induced liver injury |
| url | https://teknolabjournal.com/index.php/Jtl/article/view/445 |
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