Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions
Abstract Cortical network undergoes rewiring everyday due to learning and memory events. To investigate the trends of population adaptation in neocortex overtime, we record cellular activity of large-scale cortical populations in response to neutral environments and conditioned contexts and identify...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07186-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846164947777617920 |
|---|---|
| author | Hong Xie Kaiyuan Liu Dong Li Chang-Shui Zhang Claus C. Hilgetag Ji-Song Guan |
| author_facet | Hong Xie Kaiyuan Liu Dong Li Chang-Shui Zhang Claus C. Hilgetag Ji-Song Guan |
| author_sort | Hong Xie |
| collection | DOAJ |
| description | Abstract Cortical network undergoes rewiring everyday due to learning and memory events. To investigate the trends of population adaptation in neocortex overtime, we record cellular activity of large-scale cortical populations in response to neutral environments and conditioned contexts and identify a general intrinsic cortical adaptation mechanism, naming rectified activity-dependent population plasticity (RAPP). Comparing each adjacent day, the previously activated neurons reduce activity, but remain with residual potentiation, and increase population variability in proportion to their activity during previous recall trials. RAPP predicts both the decay of context-induced activity patterns and the emergence of sparse memory traces. Simulation analysis reveal that the local inhibitory connections might account for the residual potentiation in RAPP. Intriguingly, introducing the RAPP phenomenon in the artificial neural network show promising improvement in small sample size pattern recognition tasks. Thus, RAPP represents a phenomenon of cortical adaptation, contributing to the emergence of long-lasting memory and high cognitive functions. |
| format | Article |
| id | doaj-art-0177def660ae46e7ad20e3d416e3b761 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-0177def660ae46e7ad20e3d416e3b7612024-11-17T12:42:30ZengNature PortfolioCommunications Biology2399-36422024-11-017111410.1038/s42003-024-07186-2Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functionsHong Xie0Kaiyuan Liu1Dong Li2Chang-Shui Zhang3Claus C. Hilgetag4Ji-Song Guan5School of Artificial Intelligence Science and Technology, University of Shanghai for Science and TechnologySchool of Life Science and Technology, Shanghai Tech UniversityInstitut für Computational Neuroscience, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52Department of Automation, Tsinghua UniversityInstitut für Computational Neuroscience, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52School of Life Science and Technology, Shanghai Tech UniversityAbstract Cortical network undergoes rewiring everyday due to learning and memory events. To investigate the trends of population adaptation in neocortex overtime, we record cellular activity of large-scale cortical populations in response to neutral environments and conditioned contexts and identify a general intrinsic cortical adaptation mechanism, naming rectified activity-dependent population plasticity (RAPP). Comparing each adjacent day, the previously activated neurons reduce activity, but remain with residual potentiation, and increase population variability in proportion to their activity during previous recall trials. RAPP predicts both the decay of context-induced activity patterns and the emergence of sparse memory traces. Simulation analysis reveal that the local inhibitory connections might account for the residual potentiation in RAPP. Intriguingly, introducing the RAPP phenomenon in the artificial neural network show promising improvement in small sample size pattern recognition tasks. Thus, RAPP represents a phenomenon of cortical adaptation, contributing to the emergence of long-lasting memory and high cognitive functions.https://doi.org/10.1038/s42003-024-07186-2 |
| spellingShingle | Hong Xie Kaiyuan Liu Dong Li Chang-Shui Zhang Claus C. Hilgetag Ji-Song Guan Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions Communications Biology |
| title | Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| title_full | Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| title_fullStr | Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| title_full_unstemmed | Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| title_short | Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| title_sort | rectified activity dependent population plasticity implicates cortical adaptation for memory and cognitive functions |
| url | https://doi.org/10.1038/s42003-024-07186-2 |
| work_keys_str_mv | AT hongxie rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions AT kaiyuanliu rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions AT dongli rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions AT changshuizhang rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions AT clauschilgetag rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions AT jisongguan rectifiedactivitydependentpopulationplasticityimplicatescorticaladaptationformemoryandcognitivefunctions |