Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence

Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence

Abstract Iron and heme are essential nutrients for all branches of life. Pathogenic members of the Bacteroidota phylum, including Porphyromonas gingivalis, do not synthesize heme and rely on host hemoproteins for heme as a source of iron and protoporphyrin IX. P. gingivalis is the main pathogen resp...

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Bibliographic Details
Main Authors: Michał Śmiga, Paulina Ślęzak, Michał Tracz, Patryk Cierpisz, Mateusz Wagner, Teresa Olczak
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Porphyromonas gingivalis
Hmu system
Hus system
Heme uptake
Heme and iron homeostasis
Periodontal diseases
Online Access:https://doi.org/10.1038/s41598-024-82326-6
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