Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey
Abstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a pop...
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BMC
2025-01-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01556-w |
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| author | Renyue Ji Haisheng Wu Hongli Lin Yang Li Yumeng Shi |
| author_facet | Renyue Ji Haisheng Wu Hongli Lin Yang Li Yumeng Shi |
| author_sort | Renyue Ji |
| collection | DOAJ |
| description | Abstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a population with dysregulated glucose metabolism. Method This cross-sectional study includes 7326 patients with diabetes and prediabetes from the National Health and Nutrition Examination Survey from 2011 to 2018. The exposure variables are five environmental heavy metals—cadmium (Cd), lead (Pb), mercury (Hg), selenium (Se), and manganese (Mn)—and the endpoint is CHF, determined via face-to-face interviews. Logistic regression, weighted quantile sum (WQS), and Bayesian kernel machine learning (BKMR) models were employed to investigate the association between exposure to mixtures of five heavy metals and the odds of having CHF in individuals with diabetes and prediabetes. Result Multivariate logistic regression analysis Shows that only blood Cd exhibited a significant linear positive correlation with CHF odds (OR: 1.26, 95%CI 1.07–1.47, p = 0.005), there was a significant 14% decrease in the odds rate of CHF for each additional standard deviation of log10 Se (OR: 0.86,95%CI 0.76–0.96, P = 0.009). The WQS index for the metal mixture only marginally increased the odds of CHF by 1% (OR = 1.01, 95% CI 1.00–1.02, P = 0.032). BKMR analysis demonstrated a positive association between Cd levels and the odds of CHF, an inverse relationship with Se levels in patients with diabetes and prediabetes. However, no significant association was observed between the metal mixture and CHF. Conclusion This cross-sectional study demonstrates that increased Cd levels are associated with a higher odds of CHF in patients with diabetes and pre-diabetes, whereas elevated blood Se levels significantly mitigate this odds. |
| format | Article |
| id | doaj-art-016b4cef61d14511ac3fe4f3ffc1bdb1 |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-016b4cef61d14511ac3fe4f3ffc1bdb12025-01-12T12:33:34ZengBMCDiabetology & Metabolic Syndrome1758-59962025-01-0117111210.1186/s13098-024-01556-wCadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination surveyRenyue Ji0Haisheng Wu1Hongli Lin2Yang Li3Yumeng Shi4School of Public Health, LKS Faculty of Medicine, The University of Hong KongSchool of Public Health, LKS Faculty of Medicine, The University of Hong KongSchool of Public Health, LKS Faculty of Medicine, The University of Hong KongSchool of Public Health, LKS Faculty of Medicine, The University of Hong KongSchool of Public Health, LKS Faculty of Medicine, The University of Hong KongAbstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a population with dysregulated glucose metabolism. Method This cross-sectional study includes 7326 patients with diabetes and prediabetes from the National Health and Nutrition Examination Survey from 2011 to 2018. The exposure variables are five environmental heavy metals—cadmium (Cd), lead (Pb), mercury (Hg), selenium (Se), and manganese (Mn)—and the endpoint is CHF, determined via face-to-face interviews. Logistic regression, weighted quantile sum (WQS), and Bayesian kernel machine learning (BKMR) models were employed to investigate the association between exposure to mixtures of five heavy metals and the odds of having CHF in individuals with diabetes and prediabetes. Result Multivariate logistic regression analysis Shows that only blood Cd exhibited a significant linear positive correlation with CHF odds (OR: 1.26, 95%CI 1.07–1.47, p = 0.005), there was a significant 14% decrease in the odds rate of CHF for each additional standard deviation of log10 Se (OR: 0.86,95%CI 0.76–0.96, P = 0.009). The WQS index for the metal mixture only marginally increased the odds of CHF by 1% (OR = 1.01, 95% CI 1.00–1.02, P = 0.032). BKMR analysis demonstrated a positive association between Cd levels and the odds of CHF, an inverse relationship with Se levels in patients with diabetes and prediabetes. However, no significant association was observed between the metal mixture and CHF. Conclusion This cross-sectional study demonstrates that increased Cd levels are associated with a higher odds of CHF in patients with diabetes and pre-diabetes, whereas elevated blood Se levels significantly mitigate this odds.https://doi.org/10.1186/s13098-024-01556-wHeavy metalsCongestive heart failureDiabetesPrediabetesNHANES |
| spellingShingle | Renyue Ji Haisheng Wu Hongli Lin Yang Li Yumeng Shi Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey Diabetology & Metabolic Syndrome Heavy metals Congestive heart failure Diabetes Prediabetes NHANES |
| title | Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey |
| title_full | Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey |
| title_fullStr | Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey |
| title_full_unstemmed | Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey |
| title_short | Cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey |
| title_sort | cadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients a cross sectional study from the national health and nutrition examination survey |
| topic | Heavy metals Congestive heart failure Diabetes Prediabetes NHANES |
| url | https://doi.org/10.1186/s13098-024-01556-w |
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