Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance

Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance

Due to the lack of efficacy of the currently used chemical drugs, poor tick control, and lack of effective vaccines against Babesia, novel control strategies are urgently needed. In this regard, searching for anti-Babesia gene therapy may facilitate the control of this infection. Following this patt...

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Bibliographic Details
Main Authors: Shimaa A. E-S. El-Sayed, Mohamed A. Rizk, Hang Li, Uday Kumar Mohanta, Iqra Zafar, Shengwei Ji, Zhuowei Ma, Thom Do, Yongchang Li, Daisuke Kondoh, Jerzy Jaroszewski, Xuenan Xuan
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Babesia
gene delivery system
chitosan nanoparticles
RNAi
noncanonical pathway
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2438658
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