慢性肾病与卒中的因果关系：一项两样本双向孟德尔随机化研究Causality between Chronic Kidney Disease and Stroke: A Two-Sample Bidirectional Mendelian Randomization Study
目的 采用两样本双向孟德尔随机化（Mendelian randomization，MR）方法分析慢性肾病（chronic kidney disease，CKD）与卒中之间的因果关系。 方法 正向研究以CKD为暴露因素，卒中为结局变量，获取CKD和卒中的全基因组关联分析数据，筛选出与CKD显著相关的单核苷酸多态性（single nucleotide polymorphism，SNP）作为工具变量。反向研究则筛选与卒中密切相关的SNP作为工具变量，CKD作为结局变量。使用逆方差加权法、加权中位数法和MR-Egger回归法进行双向MR分析，探讨CKD与卒中的因果关系。通过Cochran’s Q检验...
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Chinese Journal of Stroke
2024-12-01
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| Series: | Zhongguo cuzhong zazhi |
| Subjects: | |
| Online Access: | https://www.chinastroke.org.cn/CN/10.3969/j.issn.1673-5765.2024.12.009 |
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