Trigonelline nanocrystal-based topical creams for the treatment of hair loss
This study aimed to develop a topical nanoparticulate form of trigonelline to enhance delivery to hair follicles and promote hair growth, addressing the limitations of conventional topicals. Trigonelline nanocrystals were synthesized using sonoprecipitation and optimized through the Box–Behnken desi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/japtr/fulltext/2024/15040/trigonelline_nanocrystal_based_topical_creams_for.9.aspx |
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| _version_ | 1846121834958815232 |
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| author | K. Shreya Shetty Marina Koland Ashwini, M. Marina |
| author_facet | K. Shreya Shetty Marina Koland Ashwini, M. Marina |
| author_sort | K. Shreya Shetty |
| collection | DOAJ |
| description | This study aimed to develop a topical nanoparticulate form of trigonelline to enhance delivery to hair follicles and promote hair growth, addressing the limitations of conventional topicals. Trigonelline nanocrystals were synthesized using sonoprecipitation and optimized through the Box–Behnken design. The optimized nanocrystals were analyzed using scanning and transmission electron microscopy. In vitro permeation and in-vivo skin irritation tests were conducted. The effect on hair length and density was evaluated in cyclophosphamide-induced alopecia in Wistar rats. The optimized nanocrystals had a particle size of 142.7 nm, a polydispersity index of 0.137, and a zeta potential of −25.9 mV. The topical cream contained 79.0% drug. In vitro studies showed higher flux with high Trigonelline loading. In vivo tests indicated the product was innocuous. Hair length and density were significantly greater (P < 0.01) in the nanocrystal-treated group compared to controls and commercial hair oil, but not greater than the Minoxidil group after 30 days. Nanocrystal-based trigonelline formulations show promise for treating alopecia, potentially offering an alternative to minoxidil and finasteride. |
| format | Article |
| id | doaj-art-00fd5e4aa49a48fea6c121b853ad106f |
| institution | Kabale University |
| issn | 0976-2094 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj-art-00fd5e4aa49a48fea6c121b853ad106f2024-12-15T10:33:28ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research0976-20942024-10-0115429730310.4103/JAPTR.JAPTR_26_24Trigonelline nanocrystal-based topical creams for the treatment of hair lossK. Shreya ShettyMarina KolandAshwini, M. MarinaThis study aimed to develop a topical nanoparticulate form of trigonelline to enhance delivery to hair follicles and promote hair growth, addressing the limitations of conventional topicals. Trigonelline nanocrystals were synthesized using sonoprecipitation and optimized through the Box–Behnken design. The optimized nanocrystals were analyzed using scanning and transmission electron microscopy. In vitro permeation and in-vivo skin irritation tests were conducted. The effect on hair length and density was evaluated in cyclophosphamide-induced alopecia in Wistar rats. The optimized nanocrystals had a particle size of 142.7 nm, a polydispersity index of 0.137, and a zeta potential of −25.9 mV. The topical cream contained 79.0% drug. In vitro studies showed higher flux with high Trigonelline loading. In vivo tests indicated the product was innocuous. Hair length and density were significantly greater (P < 0.01) in the nanocrystal-treated group compared to controls and commercial hair oil, but not greater than the Minoxidil group after 30 days. Nanocrystal-based trigonelline formulations show promise for treating alopecia, potentially offering an alternative to minoxidil and finasteride.https://journals.lww.com/japtr/fulltext/2024/15040/trigonelline_nanocrystal_based_topical_creams_for.9.aspxalopecia; box–behnken design; fenugreek seed; nanocrystals; trigonelline |
| spellingShingle | K. Shreya Shetty Marina Koland Ashwini, M. Marina Trigonelline nanocrystal-based topical creams for the treatment of hair loss Journal of Advanced Pharmaceutical Technology & Research alopecia; box–behnken design; fenugreek seed; nanocrystals; trigonelline |
| title | Trigonelline nanocrystal-based topical creams for the treatment of hair loss |
| title_full | Trigonelline nanocrystal-based topical creams for the treatment of hair loss |
| title_fullStr | Trigonelline nanocrystal-based topical creams for the treatment of hair loss |
| title_full_unstemmed | Trigonelline nanocrystal-based topical creams for the treatment of hair loss |
| title_short | Trigonelline nanocrystal-based topical creams for the treatment of hair loss |
| title_sort | trigonelline nanocrystal based topical creams for the treatment of hair loss |
| topic | alopecia; box–behnken design; fenugreek seed; nanocrystals; trigonelline |
| url | https://journals.lww.com/japtr/fulltext/2024/15040/trigonelline_nanocrystal_based_topical_creams_for.9.aspx |
| work_keys_str_mv | AT kshreyashetty trigonellinenanocrystalbasedtopicalcreamsforthetreatmentofhairloss AT marinakoland trigonellinenanocrystalbasedtopicalcreamsforthetreatmentofhairloss AT ashwinimmarina trigonellinenanocrystalbasedtopicalcreamsforthetreatmentofhairloss |