A New Bromo-Mn(II) Complex with 1,3,5-Triazine Derivative: Synthesis, Crystal Structure, DFT and Biological Studies
The crystal structure and topology analyses of a new bromo-Mn(II) complex with 2,4-<i>bis</i>(3,5dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (MBPT) were reported. Its structure was confirmed using single-crystal X-ray diffraction to create the formula [Mn(MBPT)B...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/12/11/284 |
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| Summary: | The crystal structure and topology analyses of a new bromo-Mn(II) complex with 2,4-<i>bis</i>(3,5dimethyl-1<i>H</i>-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (MBPT) were reported. Its structure was confirmed using single-crystal X-ray diffraction to create the formula [Mn(MBPT)Br(H<sub>2</sub>O)<sub>2</sub>]ClO<sub>4</sub>. Its crystal system was monoclinic and its space group was <i>p2<sub>1</sub></i>. The Mn(II) was coordinated with MBPT as a <i>NNN</i>-pincer ligand, with one bromide ion in the equatorial plane. The two axial terminals were occupied by two <i>trans</i> water molecules. H…H, N…H, Br…H, C…H and O…H were the predominant intermolecular contacts, while Br…H, O…H and C…O were the significant contacts based on Hirshfeld analysis. Moreover, anion–<span style="font-variant: small-caps;">ᴨ</span> interaction was found between C(<i>s</i>-triazine) and O(perchlorate). This complex had better antioxidant activity than the free ligand (MBPT). In addition, the cytotoxicity of the [Mn(MBPT)Br(H<sub>2</sub>O)<sub>2</sub>]ClO<sub>4</sub> complex showed better results against HepG-2 and MCF-7 cells, recording IC<sub>50</sub> values of 31.11 ± 2.04 and 50.05 ± 2.16 µM, respectively, compared to the free ligand (IC<sub>50</sub> = 671.44 ± 21.41 and 1113.55 ± 29.77 µM). In comparison to <i>cis</i>-platin as a reference drug, the IC<sub>50</sub> values were 63 and 80 μM, respectively, which indicated the promising anticancer activity of the studied compound against both cell lines. In terms of the safety of normal cells, the Mn(II) complex recorded a high IC<sub>50</sub> value of 359.10 ± 8.72 µM against the WI-38 non-cancerous cell line. The complex showed better activity towards <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i>, and <i>Proteus vulgaris</i> relative to the free MBPT, but had low to moderate activity compared to Gentamycin as an antibacterial positive control. |
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| ISSN: | 2304-6740 |