Distinctive Effects of Fullerene C<sub>60</sub> and Fullerenol C<sub>60</sub>(OH)<sub>24</sub> Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer’s Disease in APPswe/PS1E9 Mice

Distinctive Effects of Fullerene C<sub>60</sub> and Fullerenol C<sub>60</sub>(OH)<sub>24</sub> Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer’s Disease in APPswe/PS1E9 Mice

Fullerenes and fullerenols exhibit antioxidant and anti-inflammatory properties, making them promising candidates for Alzheimer’s disease (AD) therapy. Unlike conventional anti-inflammatory drugs, these compounds have multitargeted effects, including their ability to inhibit amyloid fibril formation...

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Main Authors: Sholpan Askarova, Kseniia Sitdikova, Aliya Kassenova, Kirill Chaprov, Evgeniy Svirin, Andrey Tsoy, Johannes de Munter, Anna Gorlova, Aleksandr Litavrin, Aleksei Deikin, Andrey Nedorubov, Nurbol Appazov, Allan Kalueff, Anton Chernopiatko, Tatyana Strekalova
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
antioxidants
fullerene C<sub>60</sub>
fullerenol C<sub>60</sub>(OH)<sub>24</sub>
APPswe/PS1E9 mice
Online Access:https://www.mdpi.com/2076-3921/14/7/834
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