Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia
Chemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/12/596 |
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| author | Ruah Alyamany Ahmed Alnughmush Hazzaa Alzahrani Mansour Alfayez |
| author_facet | Ruah Alyamany Ahmed Alnughmush Hazzaa Alzahrani Mansour Alfayez |
| author_sort | Ruah Alyamany |
| collection | DOAJ |
| description | Chemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment continuity, and overall survival. The use of growth factors, including granulocyte colony-stimulating factors (GCSFs), erythropoietin-stimulating agents (ESAs), and thrombopoietin receptor agonists (TPO-RAs), has emerged as a promising strategy for managing CIC. However, the use of these growth factors must be approached with caution. This review provides an overview of the mechanisms, efficacy, and safety of growth factors in the management of CIC. Additionally, we discuss predictive markers for treatment response, potential risks, and highlight areas for future research. |
| format | Article |
| id | doaj-art-00948e6ed2f249aaabd5690b3684e5f7 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-00948e6ed2f249aaabd5690b3684e5f72024-12-27T14:20:05ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-0131128094810910.3390/curroncol31120596Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced CytopeniaRuah Alyamany0Ahmed Alnughmush1Hazzaa Alzahrani2Mansour Alfayez3Department of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaDepartment of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaDepartment of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaDepartment of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi ArabiaChemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment continuity, and overall survival. The use of growth factors, including granulocyte colony-stimulating factors (GCSFs), erythropoietin-stimulating agents (ESAs), and thrombopoietin receptor agonists (TPO-RAs), has emerged as a promising strategy for managing CIC. However, the use of these growth factors must be approached with caution. This review provides an overview of the mechanisms, efficacy, and safety of growth factors in the management of CIC. Additionally, we discuss predictive markers for treatment response, potential risks, and highlight areas for future research.https://www.mdpi.com/1718-7729/31/12/596chemotherapy-induced cytopeniagrowth factorscytopeniaadverse effects |
| spellingShingle | Ruah Alyamany Ahmed Alnughmush Hazzaa Alzahrani Mansour Alfayez Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia Current Oncology chemotherapy-induced cytopenia growth factors cytopenia adverse effects |
| title | Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia |
| title_full | Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia |
| title_fullStr | Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia |
| title_full_unstemmed | Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia |
| title_short | Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia |
| title_sort | let it grow the role of growth factors in managing chemotherapy induced cytopenia |
| topic | chemotherapy-induced cytopenia growth factors cytopenia adverse effects |
| url | https://www.mdpi.com/1718-7729/31/12/596 |
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