Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children
Abstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83471-8 |
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| author | Daisuke Watanabe Sanae Otawa Megumi Kushima Hideki Yui Ryoji Shinohara Zentaro Yamagata Daiju Sakurai Kunio Miyake The Yamanashi Adjunct Study of the Japan Environment and Children’s Study Group |
| author_facet | Daisuke Watanabe Sanae Otawa Megumi Kushima Hideki Yui Ryoji Shinohara Zentaro Yamagata Daiju Sakurai Kunio Miyake The Yamanashi Adjunct Study of the Japan Environment and Children’s Study Group |
| author_sort | Daisuke Watanabe |
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| description | Abstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children. |
| format | Article |
| id | doaj-art-0081d9a1edf440db9e1ed84bcafb654e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0081d9a1edf440db9e1ed84bcafb654e2025-01-05T12:28:22ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-83471-8Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged childrenDaisuke Watanabe0Sanae Otawa1Megumi Kushima2Hideki Yui3Ryoji Shinohara4Zentaro Yamagata5Daiju Sakurai6Kunio Miyake7The Yamanashi Adjunct Study of the Japan Environment and Children’s Study GroupDepartment of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiDepartment of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of YamanashiDepartment of Epidemiology and Environmental Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of YamanashiAbstract This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children’s Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.70 U/mL) or higher. A total of 656 children (53.4%) were identified as sensitized to house dust mite-specific IgE, comprising 362 (60.6%) boys and 294 (46.5%) girls. For Japanese cedar pollen (JCP)-specific IgE, 820 (68.6%) children were sensitized, with 430 (73.1%) boys and 390 (64.1%) girls. Among children with AR, 40.2% of those with PAR and 78.4% of those with SAR experienced moderate to severe nasal symptoms. This study highlighted the high prevalence of JCP-specific IgE sensitization among school-aged children in Japan and provided insights into the severity of AR symptoms and the impact on QOL in these children.https://doi.org/10.1038/s41598-024-83471-8Allergic rhinitisQuality of lifeSchool-aged childrenSeasonal allergic rhinitis (SAR)SeveritySpecific IgE antibodies |
| spellingShingle | Daisuke Watanabe Sanae Otawa Megumi Kushima Hideki Yui Ryoji Shinohara Zentaro Yamagata Daiju Sakurai Kunio Miyake The Yamanashi Adjunct Study of the Japan Environment and Children’s Study Group Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children Scientific Reports Allergic rhinitis Quality of life School-aged children Seasonal allergic rhinitis (SAR) Severity Specific IgE antibodies |
| title | Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children |
| title_full | Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children |
| title_fullStr | Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children |
| title_full_unstemmed | Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children |
| title_short | Association between allergen-specific immunoglobulin E sensitization, allergic rhinitis symptoms, and quality of life in school-aged children |
| title_sort | association between allergen specific immunoglobulin e sensitization allergic rhinitis symptoms and quality of life in school aged children |
| topic | Allergic rhinitis Quality of life School-aged children Seasonal allergic rhinitis (SAR) Severity Specific IgE antibodies |
| url | https://doi.org/10.1038/s41598-024-83471-8 |
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