Sulfur-containing heterocyclic compounds with potential antidiabetic activity
The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit...
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2014-12-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/1161 |
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| author | E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev |
| author_facet | E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev |
| author_sort | E. A. Savateeva |
| collection | DOAJ |
| description | The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction. |
| format | Article |
| id | doaj-art-008059b272434232b434dd5798b4ba3c |
| institution | Kabale University |
| issn | 2411-1414 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-008059b272434232b434dd5798b4ba3c2024-12-25T09:36:53ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142014-12-0113838610.15826/chimtech.2014.1.3.11611108Sulfur-containing heterocyclic compounds with potential antidiabetic activityE. A. Savateeva0V. V. Emelyanov1A. V. Musalnikova2L. P. Sidorova3N. E. Maksimova4N. N. Machulskaya5V. A. Chereshnev6Уральский федеральный университет, ЕкатеринбургУральский федеральный университет, ЕкатеринбургУральский федеральный университет, ЕкатеринбургУральский федеральный университет, ЕкатеринбургУральский федеральный университет, ЕкатеринбургУральский федеральный университет, ЕкатеринбургУральский федеральный университет, Институт иммунологии УрО РАН, ЕкатеринбургThe essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.https://chimicatechnoacta.ru/article/view/11611,3,4-тиадиазиныпротиводиабетическая активностьнеферментативное гликозилирование белковскринингструктура-активность |
| spellingShingle | E. A. Savateeva V. V. Emelyanov A. V. Musalnikova L. P. Sidorova N. E. Maksimova N. N. Machulskaya V. A. Chereshnev Sulfur-containing heterocyclic compounds with potential antidiabetic activity Chimica Techno Acta 1,3,4-тиадиазины противодиабетическая активность неферментативное гликозилирование белков скрининг структура-активность |
| title | Sulfur-containing heterocyclic compounds with potential antidiabetic activity |
| title_full | Sulfur-containing heterocyclic compounds with potential antidiabetic activity |
| title_fullStr | Sulfur-containing heterocyclic compounds with potential antidiabetic activity |
| title_full_unstemmed | Sulfur-containing heterocyclic compounds with potential antidiabetic activity |
| title_short | Sulfur-containing heterocyclic compounds with potential antidiabetic activity |
| title_sort | sulfur containing heterocyclic compounds with potential antidiabetic activity |
| topic | 1,3,4-тиадиазины противодиабетическая активность неферментативное гликозилирование белков скрининг структура-активность |
| url | https://chimicatechnoacta.ru/article/view/1161 |
| work_keys_str_mv | AT easavateeva sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT vvemelyanov sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT avmusalnikova sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT lpsidorova sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT nemaksimova sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT nnmachulskaya sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity AT vachereshnev sulfurcontainingheterocycliccompoundswithpotentialantidiabeticactivity |