Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan
Chitosan nanoparticles have emerged as promising carriers for curcumin delivery due to their biocompatibility, biodegradability, and mucoadhesive properties. This study investigates the development and characterization of chitosan nanoparticles for efficient curcumin encapsulation and controlled rel...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Next Nanotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949829524000469 |
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| author | Hananeh Pourbagher Bahman Sharifzadeh Mazyar Ahmadi Golsefidi Seyyedeh Sahra Mirmasoudi |
| author_facet | Hananeh Pourbagher Bahman Sharifzadeh Mazyar Ahmadi Golsefidi Seyyedeh Sahra Mirmasoudi |
| author_sort | Hananeh Pourbagher |
| collection | DOAJ |
| description | Chitosan nanoparticles have emerged as promising carriers for curcumin delivery due to their biocompatibility, biodegradability, and mucoadhesive properties. This study investigates the development and characterization of chitosan nanoparticles for efficient curcumin encapsulation and controlled release. Chitosan nanoparticles were prepared using an ionic gelation method with sodium tripolyphosphate (Na-TPP) as a crosslinking agent. The influence of various parameters, such as chitosan/curcumin ratio and Na-TPP concentration, on the particle size, zeta potential, encapsulation efficiency, and in vitro curcumin release profile were evaluated. The results demonstrated that the chitosan nanoparticles possessed spherical morphology with a size range of 50–100 nm and a positive surface charge. The encapsulation efficiency was significantly influenced by the chitosan/curcumin ratio, with higher ratios leading to increased encapsulation. In vitro curcumin release studies revealed a sustained release pattern over a period of 24 h, indicating the potential of chitosan nanoparticles for controlled delivery of curcumin. These findings suggest that chitosan nanoparticles hold great promise as a drug delivery system for curcumin with enhanced therapeutic efficacy. |
| format | Article |
| id | doaj-art-007f2320acb24449bfe77f933e7e202a |
| institution | Kabale University |
| issn | 2949-8295 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Nanotechnology |
| spelling | doaj-art-007f2320acb24449bfe77f933e7e202a2024-12-09T04:28:48ZengElsevierNext Nanotechnology2949-82952024-01-016100085Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of GorganHananeh Pourbagher0Bahman Sharifzadeh1Mazyar Ahmadi Golsefidi2Seyyedeh Sahra Mirmasoudi3Ghadr Institute of Higher Education, Department of Pharmaceutical Chemistry, Koochesfahan, Guilan, IranDepartment of Engineering Sciences, Faculty of Technology and Engineering East of Guilan, University of Guilan, Rudsar, Iran; Corresponding author.Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, IranBurn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, IranChitosan nanoparticles have emerged as promising carriers for curcumin delivery due to their biocompatibility, biodegradability, and mucoadhesive properties. This study investigates the development and characterization of chitosan nanoparticles for efficient curcumin encapsulation and controlled release. Chitosan nanoparticles were prepared using an ionic gelation method with sodium tripolyphosphate (Na-TPP) as a crosslinking agent. The influence of various parameters, such as chitosan/curcumin ratio and Na-TPP concentration, on the particle size, zeta potential, encapsulation efficiency, and in vitro curcumin release profile were evaluated. The results demonstrated that the chitosan nanoparticles possessed spherical morphology with a size range of 50–100 nm and a positive surface charge. The encapsulation efficiency was significantly influenced by the chitosan/curcumin ratio, with higher ratios leading to increased encapsulation. In vitro curcumin release studies revealed a sustained release pattern over a period of 24 h, indicating the potential of chitosan nanoparticles for controlled delivery of curcumin. These findings suggest that chitosan nanoparticles hold great promise as a drug delivery system for curcumin with enhanced therapeutic efficacy.http://www.sciencedirect.com/science/article/pii/S2949829524000469Drug DeliveryCurcuminChitinNano Chitosan |
| spellingShingle | Hananeh Pourbagher Bahman Sharifzadeh Mazyar Ahmadi Golsefidi Seyyedeh Sahra Mirmasoudi Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan Next Nanotechnology Drug Delivery Curcumin Chitin Nano Chitosan |
| title | Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan |
| title_full | Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan |
| title_fullStr | Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan |
| title_full_unstemmed | Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan |
| title_short | Evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the Gulf of Gorgan |
| title_sort | evaluation of drug delivery performance of curcumin by chitosan synthesized from the skin of the shrimp of the gulf of gorgan |
| topic | Drug Delivery Curcumin Chitin Nano Chitosan |
| url | http://www.sciencedirect.com/science/article/pii/S2949829524000469 |
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