Active withdrawal of corticosteroids using tocilizumab and its association with autoantibody profiles in relapsed Takayasu arteritis: a multicentre, single-arm, prospective study (the Ab-TAK study)

Active withdrawal of corticosteroids using tocilizumab and its association with autoantibody profiles in relapsed Takayasu arteritis: a multicentre, single-arm, prospective study (the Ab-TAK study)

ObjectivesThe feasibility of corticosteroid withdrawal (CW) for Takayasu arteritis (TAK) remains uncertain. Two autoantibodies (Abs) are identified against endothelial protein C receptor (EPCR) and scavenger receptor class B type 1 (SR-BI) in TAK, determining its three subgroups. This study aimed to...

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Bibliographic Details
Main Authors: Tsuyoshi Shirai, Tomonori Ishii, Soshi Okazaki, Yuko Shirota, Yusho Ishii, Hiroko Sato, Hiroshi Fujii
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
autoantibody
corticosteroid
Takayasu arteritis
tocilizumab
withdrawal
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473100/full
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