Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province
Abstract To investigate the population distribution characteristics of elderly osteoporosis fracture patients in Hebei Province and analyze the effects of air pollutants on elderly osteoporosis fractures, We retrospectively collected 18,933 cases of elderly osteoporosis fractures from January 1, 201...
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Nature Portfolio
2024-12-01
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| author | Guangzhao Hou Qian Xiao Zhipeng Ye Shihang Liu Shuai Zhou Yan Wang Wenjing Li Yingze Zhang Hongzhi Lv |
| author_facet | Guangzhao Hou Qian Xiao Zhipeng Ye Shihang Liu Shuai Zhou Yan Wang Wenjing Li Yingze Zhang Hongzhi Lv |
| author_sort | Guangzhao Hou |
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| description | Abstract To investigate the population distribution characteristics of elderly osteoporosis fracture patients in Hebei Province and analyze the effects of air pollutants on elderly osteoporosis fractures, We retrospectively collected 18,933 cases of elderly osteoporosis fractures from January 1, 2019, to December 31, 2022, from four hospitals in Hebei Province. The average age was 76.44 ± 7.58 years, predominantly female (13,189 patients, 69.66%). The number of hospitalized patients increased progressively from 2019 to 2022. The Distribution Lag Nonlinear Model (DLNM) showed that the cumulative lagged effects of PM2.5 and PM10 on the number of hospitalized elderly osteoporosis fracture patients exhibited a bimodal distribution, with the Relative Risk (RR) reaching its peak at a 1-day lag (PM2.5: RR = 1.032, 95% CI: 1.019, 1.045; PM10: RR = 1.022, 95% CI: 1.014, 1.029). Similarly, the cumulative lagged effect of NO2 displayed a bimodal pattern, with the RR peaking at a 12-day lag (RR = 1.138, 95% CI: 1.101, 1.187). The single-day lag effect of SO2 was statistically significant from day 9 to day 12, reaching its maximum at day 11 (RR = 1.054, 95% CI: 1.032, 1.71). PM2.5, PM10, NO2, and SO2 increase the risk of osteoporosis fractures in the elderly, including single-day and cumulative lag effects. Further studies are needed to explore the molecular mechanisms behind this relationship. |
| format | Article |
| id | doaj-art-00684b85c7e14de1b2738613b2c6cd3e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-00684b85c7e14de1b2738613b2c6cd3e2025-01-05T12:29:04ZengNature PortfolioScientific Reports2045-23222024-12-0114111710.1038/s41598-024-77379-6Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei ProvinceGuangzhao Hou0Qian Xiao1Zhipeng Ye2Shihang Liu3Shuai Zhou4Yan Wang5Wenjing Li6Yingze Zhang7Hongzhi Lv8Hebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteThe School of Medicine, Chinese Orthopedic Association, Chinese Association of Orthopedic Surgeon, Nankai UniversityyHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteThe School of Medicine, Chinese Orthopedic Association, Chinese Association of Orthopedic Surgeon, Nankai UniversityyHebei Provincial Key Laboratory of Orthopaedic Biomechanics, Hebei Orthopaedic Research InstituteAbstract To investigate the population distribution characteristics of elderly osteoporosis fracture patients in Hebei Province and analyze the effects of air pollutants on elderly osteoporosis fractures, We retrospectively collected 18,933 cases of elderly osteoporosis fractures from January 1, 2019, to December 31, 2022, from four hospitals in Hebei Province. The average age was 76.44 ± 7.58 years, predominantly female (13,189 patients, 69.66%). The number of hospitalized patients increased progressively from 2019 to 2022. The Distribution Lag Nonlinear Model (DLNM) showed that the cumulative lagged effects of PM2.5 and PM10 on the number of hospitalized elderly osteoporosis fracture patients exhibited a bimodal distribution, with the Relative Risk (RR) reaching its peak at a 1-day lag (PM2.5: RR = 1.032, 95% CI: 1.019, 1.045; PM10: RR = 1.022, 95% CI: 1.014, 1.029). Similarly, the cumulative lagged effect of NO2 displayed a bimodal pattern, with the RR peaking at a 12-day lag (RR = 1.138, 95% CI: 1.101, 1.187). The single-day lag effect of SO2 was statistically significant from day 9 to day 12, reaching its maximum at day 11 (RR = 1.054, 95% CI: 1.032, 1.71). PM2.5, PM10, NO2, and SO2 increase the risk of osteoporosis fractures in the elderly, including single-day and cumulative lag effects. Further studies are needed to explore the molecular mechanisms behind this relationship.https://doi.org/10.1038/s41598-024-77379-6Osteoporosis fractures in the elderlyAir pollutantsTime series studiesDLNM |
| spellingShingle | Guangzhao Hou Qian Xiao Zhipeng Ye Shihang Liu Shuai Zhou Yan Wang Wenjing Li Yingze Zhang Hongzhi Lv Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province Scientific Reports Osteoporosis fractures in the elderly Air pollutants Time series studies DLNM |
| title | Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province |
| title_full | Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province |
| title_fullStr | Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province |
| title_full_unstemmed | Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province |
| title_short | Epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants: a multi-center study in Hebei Province |
| title_sort | epidemiological characteristics of elderly osteoporosis fractures and their association with air pollutants a multi center study in hebei province |
| topic | Osteoporosis fractures in the elderly Air pollutants Time series studies DLNM |
| url | https://doi.org/10.1038/s41598-024-77379-6 |
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