Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly
Background: The prevalence of multidrug-resistant and extensively drug-resistant pathogens has led to increased reliance on broad-spectrum antimicrobials, such as tigecycline. This medicine is commonly used to treat complicated skin and intraabdominal infections as well as community-acquired pneumon...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2024-12-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5033 |
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| _version_ | 1841556063909838848 |
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| author | Hong Chin Wee Ru Shing Ng Loke Meng Ong |
| author_facet | Hong Chin Wee Ru Shing Ng Loke Meng Ong |
| author_sort | Hong Chin Wee |
| collection | DOAJ |
| description | Background: The prevalence of multidrug-resistant and extensively drug-resistant pathogens has led to increased reliance on broad-spectrum antimicrobials, such as tigecycline. This medicine is commonly used to treat complicated skin and intraabdominal infections as well as community-acquired pneumonia. However, the increasing use of tigecycline has been linked to serious complications, including acute pancreatitis.
Case description: We present a case of tigecycline-induced acute pancreatitis in a 78-year-old man with complex medical conditions, including type 2 diabetes mellitus, chronic renal insufficiency, and triple vessel disease. The patient was initially treated with tigecycline for bilateral dry gangrene of his toes. Six days after initiation of the tigecycline treatment, the patient developed symptoms of acute pancreatitis with electrocardiogram changes. Magnetic resonance imaging confirmed the diagnosis of acute pancreatitis. Tigecycline was stopped promptly, and supportive treatment was initiated. The patient recovered from the acute pancreatitis and was discharged home. He later passed away at home due to his underlying cardiac disease.
Conclusions: This case highlights the potential complications of tigecycline therapy, particularly in patients with significant comorbidities. |
| format | Article |
| id | doaj-art-00516edf18b94eaebe954409b160cc72 |
| institution | Kabale University |
| issn | 2284-2594 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-00516edf18b94eaebe954409b160cc722025-01-07T13:40:28ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942024-12-0110.12890/2024_0050334568Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderlyHong Chin Wee0Ru Shing Ng1Loke Meng Ong2Clinical Research Centre, Hospital Pulau Pinang, Georgetown, Malaysia; Ministry of Health, Putrajaya, Malaysia; Institute of Clinical Research, National Institute of Health, Shah Alam, MalaysiaClinical Research Centre, Hospital Pulau Pinang, Georgetown, Malaysia; Ministry of Health, Putrajaya, Malaysia; Institute of Clinical Research, National Institute of Health, Shah Alam, MalaysiaClinical Research Centre, Hospital Pulau Pinang, Georgetown, Malaysia; Ministry of Health, Putrajaya, Malaysia; Internal Medicine Department, Penang Adventist Hospital, Georgetown, MalaysiaBackground: The prevalence of multidrug-resistant and extensively drug-resistant pathogens has led to increased reliance on broad-spectrum antimicrobials, such as tigecycline. This medicine is commonly used to treat complicated skin and intraabdominal infections as well as community-acquired pneumonia. However, the increasing use of tigecycline has been linked to serious complications, including acute pancreatitis. Case description: We present a case of tigecycline-induced acute pancreatitis in a 78-year-old man with complex medical conditions, including type 2 diabetes mellitus, chronic renal insufficiency, and triple vessel disease. The patient was initially treated with tigecycline for bilateral dry gangrene of his toes. Six days after initiation of the tigecycline treatment, the patient developed symptoms of acute pancreatitis with electrocardiogram changes. Magnetic resonance imaging confirmed the diagnosis of acute pancreatitis. Tigecycline was stopped promptly, and supportive treatment was initiated. The patient recovered from the acute pancreatitis and was discharged home. He later passed away at home due to his underlying cardiac disease. Conclusions: This case highlights the potential complications of tigecycline therapy, particularly in patients with significant comorbidities.https://www.ejcrim.com/index.php/EJCRIM/article/view/5033tigecyclineacute pancreatitischronic renal insufficiencyadverse drug reactions |
| spellingShingle | Hong Chin Wee Ru Shing Ng Loke Meng Ong Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly European Journal of Case Reports in Internal Medicine tigecycline acute pancreatitis chronic renal insufficiency adverse drug reactions |
| title | Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| title_full | Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| title_fullStr | Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| title_full_unstemmed | Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| title_short | Tigecycline-induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| title_sort | tigecycline induced acute pancreatitis with electrocardiogram changes in renal insufficiency elderly |
| topic | tigecycline acute pancreatitis chronic renal insufficiency adverse drug reactions |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5033 |
| work_keys_str_mv | AT hongchinwee tigecyclineinducedacutepancreatitiswithelectrocardiogramchangesinrenalinsufficiencyelderly AT rushingng tigecyclineinducedacutepancreatitiswithelectrocardiogramchangesinrenalinsufficiencyelderly AT lokemengong tigecyclineinducedacutepancreatitiswithelectrocardiogramchangesinrenalinsufficiencyelderly |