Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance
Objective: The aim of this study was to evaluate the relationship between subclinical lymphedema identified prior to surgical intervention and clinical lymphedema observed in the late period, the incidence of lymphedema in our cohort, and the associated risk factors. Materials and Methods: This pro...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-01-01
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| Series: | European Journal of Breast Health |
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| Online Access: | https://www.eurjbreasthealth.com/articles/evaluation-of-long-term-lymphedema-rate-in-patients-with-subclinical-lymphedema-diagnosed-in-the-preoperative-period-via-bioimpedance/doi/ejbh.galenos.2024.2024-9-5 |
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| author | Zeynep Erdoğan İyigün Tolga Ozmen Serkan İlgün Cansu Nakipoğlu Enver Özkurt Filiz Çelebi Çağlar Ünal Alper Öztürk Gül Alço Çetin Ordu Gürsel Soybir |
| author_facet | Zeynep Erdoğan İyigün Tolga Ozmen Serkan İlgün Cansu Nakipoğlu Enver Özkurt Filiz Çelebi Çağlar Ünal Alper Öztürk Gül Alço Çetin Ordu Gürsel Soybir |
| author_sort | Zeynep Erdoğan İyigün |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate the relationship between subclinical lymphedema identified prior to surgical intervention and clinical lymphedema observed in the late period, the incidence of lymphedema in our cohort, and the associated risk factors.
Materials and Methods: This prospective study was conducted with early-stage breast cancer patients who had been enrolled in a previous study. For diagnosing lymphedema, physical examination, L-Dex® score, and circumferential measurement was used. The L-Dex® score was used as a screening test for preoperative, subclinical lymphedema since there were no clinical findings. Patients with subclinical lymphedema were provided with education and followed up more frequently with regular monitoring.
Results: The mean age of the 217 participants was 56.7±12.7 years (range 29–90), and the mean body mass index was 27.7±3.3 kg/m2 (range 19.3–36.9). Among the 217 patients, lymphedema was detected in 31 (14.7%) at a median follow-up period of 89 months (range 73–108 months). Multivariable analysis of factors associated with late-stage lymphedema revealed positive lymph node count and capsular invasion as significant factors (p = 0.001 for both). Forty (18.4%) had preoperative subclinical lymphedema. At the end of the follow-up period, lymphedema persisted in 11 patients (27.5%) and resolved in 29 patients (72.5%). In multivariable analysis, the positive lymph node count was identified as an independent variable in these patients.
Conclusion: Identifying high-risk patients, regular monitoring, and early intervention can significantly reduce the risk of clinical lymphedema through timely treatment. |
| format | Article |
| id | doaj-art-0049e5b922f64a8cb3048743f950a231 |
| institution | Kabale University |
| issn | 2587-0831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj-art-0049e5b922f64a8cb3048743f950a2312025-01-07T10:51:58ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312025-01-01211404510.4274/ejbh.galenos.2024.2024-9-5Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via BioimpedanceZeynep Erdoğan İyigün0https://orcid.org/0000-0001-5353-1452Tolga Ozmen1https://orcid.org/0000-0002-7136-6195Serkan İlgün2https://orcid.org/0000-0002-4862-2891Cansu Nakipoğlu3https://orcid.org/0000-0003-2327-2271Enver Özkurt4https://orcid.org/0000-0003-2597-3119Filiz Çelebi5https://orcid.org/0000-0003-4020-4019Çağlar Ünal6https://orcid.org/0000-0003-3245-1570Alper Öztürk7https://orcid.org/0000-0002-7137-5374Gül Alço8https://orcid.org/0000-0002-3592-9923Çetin Ordu9https://orcid.org/0000-0003-4423-8005Gürsel Soybir10https://orcid.org/0000-0003-0626-0105Department of Physical Therapy and Rehabilitation, Bahçeşehir University Faculty of Medicine, İstanbul, TurkeyDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, USACenter of Breast Health, İstanbul Florence Nightingale Hospital, İstanbul, TurkeyCenter of Breast Health, İstanbul Florence Nightingale Hospital, İstanbul, TurkeyCenter of Breast Health, İstanbul Florence Nightingale Hospital, İstanbul, TurkeyDeparment of Radiology, Yeditepe University Faculty of Medicine, İstanbul, TurkeyClinic of Oncology, University of Health Science Turkey İstanbul Kartal Lütfi Kırdar City Hospital, İstanbul, TurkeyDepartment of General Surgery, Biruni University Faculty of Medicine, İstanbul, TurkeyClinic of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, İstanbul, TurkeyClinic of Medical Oncology, Gayrettepe Florence Nightingale Hospital, İstanbul, TurkeyClinic of General Surgery, Memorial Şişli Hospital, İstanbul, TurkeyObjective: The aim of this study was to evaluate the relationship between subclinical lymphedema identified prior to surgical intervention and clinical lymphedema observed in the late period, the incidence of lymphedema in our cohort, and the associated risk factors. Materials and Methods: This prospective study was conducted with early-stage breast cancer patients who had been enrolled in a previous study. For diagnosing lymphedema, physical examination, L-Dex® score, and circumferential measurement was used. The L-Dex® score was used as a screening test for preoperative, subclinical lymphedema since there were no clinical findings. Patients with subclinical lymphedema were provided with education and followed up more frequently with regular monitoring. Results: The mean age of the 217 participants was 56.7±12.7 years (range 29–90), and the mean body mass index was 27.7±3.3 kg/m2 (range 19.3–36.9). Among the 217 patients, lymphedema was detected in 31 (14.7%) at a median follow-up period of 89 months (range 73–108 months). Multivariable analysis of factors associated with late-stage lymphedema revealed positive lymph node count and capsular invasion as significant factors (p = 0.001 for both). Forty (18.4%) had preoperative subclinical lymphedema. At the end of the follow-up period, lymphedema persisted in 11 patients (27.5%) and resolved in 29 patients (72.5%). In multivariable analysis, the positive lymph node count was identified as an independent variable in these patients. Conclusion: Identifying high-risk patients, regular monitoring, and early intervention can significantly reduce the risk of clinical lymphedema through timely treatment.https://www.eurjbreasthealth.com/articles/evaluation-of-long-term-lymphedema-rate-in-patients-with-subclinical-lymphedema-diagnosed-in-the-preoperative-period-via-bioimpedance/doi/ejbh.galenos.2024.2024-9-5breast cancerlymphedemarisk factorsearly detection |
| spellingShingle | Zeynep Erdoğan İyigün Tolga Ozmen Serkan İlgün Cansu Nakipoğlu Enver Özkurt Filiz Çelebi Çağlar Ünal Alper Öztürk Gül Alço Çetin Ordu Gürsel Soybir Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance European Journal of Breast Health breast cancer lymphedema risk factors early detection |
| title | Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance |
| title_full | Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance |
| title_fullStr | Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance |
| title_full_unstemmed | Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance |
| title_short | Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance |
| title_sort | evaluation of long term lymphedema rate in patients with subclinical lymphedema diagnosed in the preoperative period via bioimpedance |
| topic | breast cancer lymphedema risk factors early detection |
| url | https://www.eurjbreasthealth.com/articles/evaluation-of-long-term-lymphedema-rate-in-patients-with-subclinical-lymphedema-diagnosed-in-the-preoperative-period-via-bioimpedance/doi/ejbh.galenos.2024.2024-9-5 |
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