Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study
Background. Long-term use of many classic chemotherapeutic agents as adjuncts in the management of periodontitis has adverse complications, leading to seeking out naturopathic remedies. Although curcumin has been investigated in managing periodontitis, its therapeutic benefits have not been fully ex...
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Tabriz University of Medical Sciences
2023-12-01
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| Series: | Journal of Advanced Periodontology and Implant Dentistry |
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| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-15-67.pdf |
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| author | Veena HR Riya Achamma Daniel Ashwin Prabhu Shilpa P Suman Basavaraju |
| author_facet | Veena HR Riya Achamma Daniel Ashwin Prabhu Shilpa P Suman Basavaraju |
| author_sort | Veena HR |
| collection | DOAJ |
| description | Background. Long-term use of many classic chemotherapeutic agents as adjuncts in the management of periodontitis has adverse complications, leading to seeking out naturopathic remedies. Although curcumin has been investigated in managing periodontitis, its therapeutic benefits have not been fully explored due to its limited solubility in an aqueous medium. This study aimed to develop a novel target-specific drug delivery system containing 1% self-nanoemulsifying curcumin (SNEC) in a hydroxypropylmethylcellulose (HPMC) matrix and evaluate the susceptibility of periodontal pathogens to this system in vitro. Methods. Its antibacterial activity against Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans was evaluated and compared to pure nano-curcumin and SNEC alone by estimating their minimum inhibitory concentrations (MIC). Results. The antibacterial activity of pure nano-curcumin, SNEC, and SNEC in HPMC against the four periodontal pathogens evaluated in terms of MIC was recorded in the range of 0.2‒0.4, 0.4‒0.8, and 0.2‒0.8 µg/mL, respectively. However, the MIC of all three curcumin formulations against the periodontal pathogens tested was higher than that of the standard moxifloxacin. While both pure nano-curcumin and SNEC showed increasing values of inhibition zones with increasing concentrations on disk diffusion assay, lower concentrations of SNEC in HPMC did not show a zone of inhibition against the tested pathogens. Conclusion. The novel delivery system containing SNEC in HPMC may be a potential adjunct in managing periodontitis due to its probable sustained antimicrobial activity against the tested periodontal pathogens. |
| format | Article |
| id | doaj-art-0045fa6d2f9941e88f078a5a0c3b110b |
| institution | Kabale University |
| issn | 2645-5390 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj-art-0045fa6d2f9941e88f078a5a0c3b110b2024-12-11T06:00:45ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902023-12-01152677310.34172/japid.2023.024japid-3362Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro studyVeena HR0Riya Achamma Daniel1Ashwin Prabhu2Shilpa P3Suman Basavaraju4Department of Periodontology, KLE Society’s Institute of Dental Sciences, Bengaluru, KarnatakaDepartment of Dental Surgery, MIOT International, Chennai, IndiaDepartment of Periodontology, KLE Society’s Institute of Dental Sciences, Bengaluru, KarnatakaKLE Society’s Institute of Dental Sciences, Bengaluru, KarnatakaDepartment of Periodontology, JSS Dental College & Hospital, Mysuru, IndiaBackground. Long-term use of many classic chemotherapeutic agents as adjuncts in the management of periodontitis has adverse complications, leading to seeking out naturopathic remedies. Although curcumin has been investigated in managing periodontitis, its therapeutic benefits have not been fully explored due to its limited solubility in an aqueous medium. This study aimed to develop a novel target-specific drug delivery system containing 1% self-nanoemulsifying curcumin (SNEC) in a hydroxypropylmethylcellulose (HPMC) matrix and evaluate the susceptibility of periodontal pathogens to this system in vitro. Methods. Its antibacterial activity against Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans was evaluated and compared to pure nano-curcumin and SNEC alone by estimating their minimum inhibitory concentrations (MIC). Results. The antibacterial activity of pure nano-curcumin, SNEC, and SNEC in HPMC against the four periodontal pathogens evaluated in terms of MIC was recorded in the range of 0.2‒0.4, 0.4‒0.8, and 0.2‒0.8 µg/mL, respectively. However, the MIC of all three curcumin formulations against the periodontal pathogens tested was higher than that of the standard moxifloxacin. While both pure nano-curcumin and SNEC showed increasing values of inhibition zones with increasing concentrations on disk diffusion assay, lower concentrations of SNEC in HPMC did not show a zone of inhibition against the tested pathogens. Conclusion. The novel delivery system containing SNEC in HPMC may be a potential adjunct in managing periodontitis due to its probable sustained antimicrobial activity against the tested periodontal pathogens.https://japid.tbzmed.ac.ir/PDF/japid-15-67.pdfantibacterial agentscurcuminnanoparticlesperiodontitis |
| spellingShingle | Veena HR Riya Achamma Daniel Ashwin Prabhu Shilpa P Suman Basavaraju Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study Journal of Advanced Periodontology and Implant Dentistry antibacterial agents curcumin nanoparticles periodontitis |
| title | Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study |
| title_full | Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study |
| title_fullStr | Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study |
| title_full_unstemmed | Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study |
| title_short | Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study |
| title_sort | susceptibility of periodontal pathogens to a novel target specific drug delivery system containing self nanoemulsifying curcumin an in vitro study |
| topic | antibacterial agents curcumin nanoparticles periodontitis |
| url | https://japid.tbzmed.ac.ir/PDF/japid-15-67.pdf |
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