Epigenetic Inhibitors Differentially Impact TGF-β1 Signaling Cascades in COPD Airway Smooth Muscle Cells

Epigenetic Inhibitors Differentially Impact TGF-β1 Signaling Cascades in COPD Airway Smooth Muscle Cells

<b>Background:</b> Chronic obstructive pulmonary disease (COPD) is characterized by progressive and incurable airflow obstruction and chronic inflammation. Both TGF-β1 and CXCL8 have been well described as fundamental to COPD progression. DNA methylation and histone acetylation, which ar...

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Bibliographic Details
Main Authors: Karosham Diren Reddy, Dikaia Xenaki, Ian M. Adcock, Brian G. G. Oliver, Razia Zakarya
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
COPD
epigenetics
airway smooth muscle
inflammation
DNA methylation
histone acetylation
Online Access:https://www.mdpi.com/2073-4409/14/1/31
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